Degeneration affects the fiber reorientation of human annulus fibrosus under tensile load
Degeneration affects the fiber reorientation of human annulus fibrosus under tensile load
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DOI：
10.1016/j.jbiomech.2005.04.007
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发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Elliott, Dawn M.
中科院分区：
文献类型：
--
作者：
Guerin, Heather Anne L.;Elliott, Dawn M.
纤维环的成角层状结构是其承载功能的组成部分。这种纤维结构与施加的负载的重新取向可能有助于非线性力学行为和拉伸模量的大幅增加。尚未对加载的非退化和退化纤维环组织的纤维重新定向进行量化。本研究的目的是使用FFT图像处理技术的一种新的应用程序来测量加载的外部纤维环组织的纤维重定向和机械性能（趾部和线性区域模量、过渡应变和泊松比）。在本研究中，对该方法进行了验证，以量化加载期间的纤维环重新取向。我们假设纤维环纤维在周向拉伸载荷下会重新定向，并且纤维重新定向是仿射的。此外，我们假设退化会影响纤维的重新取向，趾区模量和泊松比。发现纤维环纤维朝向加载方向重新取向，并且变性显著降低纤维重新取向（纤维重新取向参数，m（FFT）=-1.70度/%应变（对于非变性组织）和-0.95度/%应变（对于变性组织））。趾区模量与年龄显著相关（r = 0.6）。配对t检验显示，实验计算的纤维重取向参数与使用仿射预测计算的无显著差异。因此，仿射预测是纤维重取向的良好近似。这项研究的结果增加了对整体椎间盘力学行为和退变的理解。(c)2005爱思唯尔有限公司保留所有权利。
The angled, lamellar structure of the annulus fibrosus is integral to its load-bearing function. Reorientation of this fiber structure with applied load may contribute to nonlinear mechanical behavior and to large increases in tensile modulus. Fiber reorientation has not yet been quantified for loaded non-degenerated and degenerated annulus fibrosus tissue. The objective of this study was to measure fiber reorientation and mechanical properties (toe- and linear-region modulus, transition strain, and Poisson's ratio) of loaded outer annulus fibrosus tissue using a new application of FFT image processing techniques. This method was validated for quantification of annulus fiber reorientation during loading in this study. We hypothesized that annulus fibrosus fibers would reorient under circumferential tensile load, and that fiber reorientation would be affine. Additionally, we hypothesized that degeneration would affect fiber reorientation, toe-region modulus and Poisson's ratio. Annulus fibrosus fibers were found to reorient toward the loading direction, and degeneration significantly decreased fiber reorientation (the fiber reorientation parameter, m(FFT) = -1.70 degrees/% strain for non-degenerated and -0.95 degrees/% strain for degenerated tissue). Toe-region modulus was significantly correlated with age (r = 0.6). Paired t-tests showed no significant difference in the fiber reorientation parameter calculated experimentally with that calculated using an affine prediction. Thus, an affine prediction is a good approximation of fiber reorientation. The findings of this study add to the understanding of overall disc mechanical behavior and degeneration. (c) 2005 Elsevier Ltd. All rights reserved.