Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy.
Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy.
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评估吲哚美辛口腔喷雾剂治疗抗癌治疗期间口咽粘膜炎引起的疼痛。
DOI：
10.1007/s00520-017-3817-2
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Homma M
中科院分区：
文献类型：
--
作者：
Momo K;Nagaoka H;Kizawa Y;Bukawa H;Chiba S;Kohda Y;Homma M
目的评价吲哚美辛（IM）口腔喷雾剂（OS）用于头颈部恶性肿瘤和血液系统肿瘤患者放疗、化疗所致口咽粘膜炎的止痛疗效和安全性（男性/女性，20/15; 53 ± 17岁），在日本筑波大学医院接受IM-OS制剂止痛治疗。在IM口腔喷雾剂治疗开始时，使用6级面部疼痛量表对28例患者的镇痛效果进行评估。全身暴露通过测定7例患者IM的尿排泄来评估。结果26例（93%）患者在应用IM-OS制剂后25（5-60）min疼痛缓解（15.6 ± 3.4）μg/kg，镇痛作用持续120（10-360）min（3.6 ± 0.7比2.4 ± 0.9，p < 0.01）。此外，应用IM喷雾制剂后的尿IM排泄率为IM经口喷雾剂量（130.5 ± 77.7 μg/kg/天）的1.8 ± 0.8%，显著低于IM经口给药后的排泄率（60%）。没有观察到不良事件后的应用程序的spray.ConclusionsThe本IM喷雾是一种有效和安全的制备疼痛缓解，并可作为一种替代的治疗选择口咽粘膜炎的癌症患者。
PurposeThe efficacy and safety of indomethacin (IM) oral spray (OS) as a pain control therapy for oropharyngeal mucositis due to anticancer chemo- and radiotherapy were assessed in patients with head and neck carcinomas and haematological tumours.MethodWe observed 35 patients (male/female, 20/15; 53 ± 17 years) with oropharyngeal mucositis who were treated with IM-OS preparation for pain relief at University of Tsukuba Hospital, Japan. Analgesic effects were assessed using the six-grade face scale for pain in 28 patients at the start of IM oral spray treatment. Systemic exposure was assessed by determining urinary excretions of IM in seven patients.ResultsPain relief was achieved in 26 (93%) patients at 25 (5–60) min after applying the IM-OS preparation (15.6 ± 3.4 μg/kg) and analgesic effects were maintained for 120 (10–360) min. The pain was significantly decreased after using the spray (3.6 ± 0.7 vs. 2.4 ± 0.9,p< 0.01). Moreover, urinary IM excretion rates after applying the IM spray preparation were 1.8 ± 0.8% of the IM oral spray dose (130.5 ± 77.7 μg/kg/day), which was markedly lower than that following oral administration of IM (60%). No adverse events were observed following application of the spray.ConclusionsThe present IM spray is an effective and safe preparation for pain relief and can be used as an alternative therapeutic option for oropharyngeal mucositis in cancer patients.