Clustering of mumps virus isolates by SH gene sequence only partially reflects geographical origin
Clustering of mumps virus isolates by SH gene sequence only partially reflects geographical origin
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DOI：
10.1007/s007050050073
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发表时间：
1997-01-01
影响因子：
2.7
通讯作者：
Minor, PD
中科院分区：
文献类型：
--
作者：
Afzal, MA;Buchanan, J;Minor, PD
本文测定了45株来自欧洲、加拿大和美国的腮腺炎病毒新分离株的SH基因的核苷酸序列。构建了系统发育树，证实了三个主要集群的存在。虽然根据地理来源的聚类在某些情况下是明确的，但每个主要聚类都包括来源广泛分离的分离株。不同菌株的SH基因序列之间的变异程度和编码与非编码差异的比率与在其他基因如M和HN中观察到的相比都非常高。建立了流行性腮腺炎病毒株的标准化命名系统。
The nucleotide sequences of the SH gene of 45 new mumps virus isolates derived from different parts of Europe, Canada and USA were determined. A phylogenetic tree was constructed which confirmed the existence of three major clusters. While clustering according to geographical origin was clear in some cases each of the major clusters included isolates which were widely separated in origin. The degree of variability between the sequences of SH genes of different strains and the ratio of coding to non coding differences were both very high compared to those observed in other genes such as the M and HN. A standardized system of nomenclature of mumps strains was established.