An optimized vaccine vector based on recombinant vesicular stomatitis virus gives high-level, long-term protection against Yersinia pestis challenge
An optimized vaccine vector based on recombinant vesicular stomatitis virus gives high-level, long-term protection against Yersinia pestis challenge
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DOI：
10.1016/j.vaccine.2006.08.010
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发表时间：
2007-01-08
期刊：
影响因子：
5.5
通讯作者：
Rose, John K.
中科院分区：
文献类型：
--
作者：
Palin, Amy;Chattopadhyay, Anasuya;Rose, John K.
We have developed recombinant vesicular stomatitis virus (VSV) vectors expressing the Yersinia pestis lcrV gene. These vectors, given intranasally to mice, induced high antibody titers to the LcrV protein and protected against intranasal (Pulmonary) challenge with Y pestis. High-level protection was dependent on using an optimized VSV vector that expressed high levels of the LcrV protein from an lcrV gene placed in the first position in the VSV genome, followed by a single boost. This VSV-based vaccine vector system has potential as a plague vaccine protecting against virulent strains lacking the F1 protein. (c) 2006 Elsevier Ltd. All rights reserved.
