p16 and p53 expression status in head and neck squamous cell carcinoma: a correlation with histological, histoprognostic and clinical parameters
p16 and p53 expression status in head and neck squamous cell carcinoma: a correlation with histological, histoprognostic and clinical parameters
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DOI：
10.1016/j.pathol.2016.01.005
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发表时间：
2016-06-01
期刊：
影响因子：
4.5
通讯作者：
Peoc'h, Michel
中科院分区：
文献类型：
--
作者：
Karpathiou, Georgia;Monaya, Alessandra;Peoc'h, Michel
不同的组织病理学和预后的人乳头状瘤病毒（HPV）相关的口咽肿瘤，但鳞状细胞癌（SCC）的其他localisations还没有得到详尽的study.Tissues从120例头颈部SCC的p16和p53的表达，和Brandwein-Gensler（BG）的组织学风险评估模型进行了研究。p16阳性和p53正常表达与不吸烟、T分期早和无角化形态显著相关。BG风险评分与p16或p53表达无关; p16表达与淋巴细胞T细胞毒性反应相关。BG风险评分与总生存期和无进展生存期显著相关，而p16和p53表达均与肿瘤相关。即使在非口咽限制性肿瘤中，p16和p53表达也与组织学亚型和T分期相关。BG风险评分与p16或p53不相关，并在非部位特异性SCC中保持其效力。
Different histopathology and prognosis characterise the human papillomavirus (HPV)-related oropharyngeal tumours, but squamous cell carcinomas (SCC) of other localisations have not been exhaustively studied.Tissues from 120 patients with a head and neck SCC were studied for the expression of p16 and p53, and the Brandwein-Gensler (BG) histological risk assessment model. p16 positivity and p53 normal expression were significantly correlated with non-smoking, an earlier T stage and a non-keratinising morphology. The BG risk score was not associated with p16 or p53 expression; p16 expression was associated with a lymphocytic T-cytotoxic response. BG risk score was significantly correlated with overall survival and progression-free survival, while neither p16 nor p53 expression were associated with prognosis.p16 and p53 expression are associated with the histological subtype and the T stage even in non-oropharyngeal-restricted tumours. The BG risk score is not correlated with p16 or p53 and retains its power in non-site-specific SCCs.