Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk.
Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk.
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DOI：
10.1523/jneurosci.0859-10.2010
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发表时间：
2010-06-02
期刊：
影响因子：
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通讯作者：
Pollak SD
中科院分区：
文献类型：
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作者：
Hanson JL;Chung MK;Avants BB;Shirtcliff EA;Gee JC;Davidson RJ;Pollak SD
经历过早期逆境（例如虐待儿童）的个人面临各种社会和健康困难的风险更高。然而，人们对这种行为风险是如何在大脑中具体化的知之甚少。在这里，我们使用适合儿科人群的方法并结合对社会行为的深入测量，研究了神经生物学对人类行为个体差异的贡献。我们发现，经历过身体虐待的人的眶额皮层的变化与社交困难有关。这些数据表明了一种将早期社会学习与后来的行为结果联系起来的生物机制。
Individuals who experience early adversity, such as child maltreatment, are at heightened risk for a broad array of social and health difficulties. However, little is known about how this behavioral risk is instantiated in the brain. Here we examine a neurobiological contribution to individual differences in human behavior using methodology appropriate for use with pediatric populations paired with an in-depth measure of social behavior. We show that alterations in the orbitofrontal cortex among individuals who experienced physical abuse are related to social difficulties. These data suggest a biological mechanism linking early social learning to later behavioral outcomes.