Methodology and Indications of H2-Breath Testing in Gastrointestinal Diseases: the Rome Consensus Conference
Methodology and Indications of H2-Breath Testing in Gastrointestinal Diseases: the Rome Consensus Conference
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DOI：
10.1111/j.1365-2036.2009.03951.x
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发表时间：
2009-05-01
影响因子：
7.6
通讯作者：
Tursi, A.
中科院分区：
文献类型：
--
作者：
Gasbarrini, A.;Corazza, G. R.;Tursi, A.
背景：呼吸测试在许多胃肠疾病中是一种有效的非侵入性诊断工具。氢呼气试验的基本原理是基于这样一个概念，即结肠细菌发酵产生的部分气体扩散到血液中，并通过呼吸排出体外，这样很容易量化。在方法上有许多不同之处，而且测试越来越受欢迎。目的：召开罗马共识会议，就h -2呼气试验在胃肠道疾病中的适应症和方法提出临床实践建议。方法根据在h -2呼气测试方面的成熟知识/专业知识选择专家，并分为工作组（方法学、糖吸收不良、小肠细菌过度生长、口-结肠运输时间和其他气体相关综合征）。他们对文献进行了系统的回顾，然后在科学证据的基础上制定了声明，这些声明由一个多学科的陪审团进行辩论和投票。然后，专家组成员根据评委会的决定修改各项建议。结果和结论根据证据水平和推荐强度进行评分的最终陈述在本文件中呈现；它们确定了在临床实践中使用h -2呼气测试的适应症和用于进行测试的方法。
Background Breath tests represent a valid and non-invasive diagnostic tool in many gastroenterological conditions. The rationale of hydrogen-breath tests is based on the concept that part of the gas produced by colonic bacterial fermentation diffuses into the blood and is excreted by breath, where it can be quantified easily. There are many differences in the methodology, and the tests are increasingly popular.Aim The Rome Consensus Conference was convened to offer recommendations for clinical practice about the indications and methods of H-2-breath testing in gastrointestinal diseases.Methods Experts were selected on the basis of a proven knowledge/expertise in H-2-breath testing and divided into Working Groups ( methodology; sugar malabsorption; small intestine bacterial overgrowth; oro-coecal transit time and other gas-related syndromes). They performed a systematic review of the literature, and then formulated statements on the basis of the scientific evidence, which were debated and voted by a multidisciplinary Jury. Recommendations were then modified on the basis of the decisions of the Jury by the members of the Expert Group.Results and conclusions The final statements, graded according to the level of evidence and strength of recommendation, are presented in this document; they identify the indications for the use of H-2-breath testing in the clinical practice and methods to be used for performing the tests.