Wrist-Worn Electrodermal Activity as a Novel Neurophysiological Biomarker of Autonomic Symptoms in Spatial Disorientation
Wrist-Worn Electrodermal Activity as a Novel Neurophysiological Biomarker of Autonomic Symptoms in Spatial Disorientation
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DOI：
10.3389/fneur.2018.01056
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发表时间：
2018-12
影响因子：
3.4
通讯作者：
A. Tamura;Tetsuya Iwamoto;H. Ozaki;Mikihiko Kimura;Yukiko Tsujimoto;Yoshiro Wada
中科院分区：
文献类型：
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作者：
A. Tamura;Tetsuya Iwamoto;H. Ozaki;Mikihiko Kimura;Yukiko Tsujimoto;Yoshiro Wada
背景：空间定向障碍是导致航空事故的最常见原因之一，也是影响航空安全的一个主要问题。虽然一些研究已经检查了空间定向障碍，但作为空间定向障碍和运动病的直接结果而发生的精确生理变化仍然不清楚。本研究旨在调查皮肤电活动（EDA）和主观自主神经症状在空间定向障碍训练，并制定一个指标的生理变化的飞行员候选人。研究方法：在目前的研究中，我们调查了EDA的变化测量使用腕戴式设备，和主观自主神经系统症状的飞行员候选人在空间定向障碍训练。然后，我们使用Graybiel诊断标准开发了一种新的生理生物标志物。结果如下：我们发现，与评分< 2分的受试者相比，Graybiel评分≥3分的受试者的最大EDA变化和峰值振幅显著增加。此外，对于冷汗和唾液分泌症状（来自七个Graybiel诊断标准），得分≥1分的参与者的最大EDA变化显著高于得分为0分的参与者。结论：我们的研究结果表明，EDA数据测量与腕戴式设备可以提供一个有用的方法来客观评价空间定向障碍和运动病的严重程度。
Background: Spatial disorientation is one of the most frequent causes of aircraft accidents, and is thus a major problem affecting air safety. Although a number of studies have examined spatial disorientation, the precise physiological changes occurring as a direct result of spatial disorientation and motion sickness remain unclear. The present study sought to investigate electrodermal activity (EDA) and subjective autonomic symptoms during spatial disorientation training, and to develop an indicator of physiological changes for pilot candidates. Methods: In the current study, we investigated changes in EDA measured using a wrist-worn device, and subjective autonomic nervous system symptoms during spatial disorientation training for pilot candidates. We then used the Graybiel diagnostic criteria to develop a novel physiological biomarker. Results: We found that maximum EDA change and peak amplitude were significantly increased in participants with a Graybiel score of ≥3 points compared with those who scored < 2 points. Furthermore, for symptoms of cold sweating and saliva secretion (from the seven Graybiel diagnostic criteria), the maximum EDA change in participants with scores ≥1 point was significantly higher than that of participants scoring 0 points. Conclusion: Our results indicate that EDA data measured with a wrist-worn device could provide a useful method for objective evaluation of the severity of spatial disorientation and motion sickness.