Adipose tissue morphology predicts improved insulin sensitivity following moderate or pronounced weight
Adipose tissue morphology predicts improved insulin sensitivity following moderate or pronounced weight
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DOI：
10.1038/ijo.2015.18
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发表时间：
2015-06-01
影响因子：
4.9
通讯作者：
Ryden, M.
中科院分区：
文献类型：
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作者：
Eriksson-Hogling, D.;Andersson, D. P.;Ryden, M.
背景技术背景：横断面研究表明，与增生（许多小脂肪细胞）相反，白色脂肪组织肥大（少数大脂肪细胞）与胰岛素抵抗和2型糖尿病风险增加有关。我们研究了基线脂肪细胞数是否可以预测体重减轻后胰岛素敏感性的改善。对100名超重或肥胖个体在低热量饮食前和低热量饮食后10周进行血浆样本和皮下腹部脂肪活检（7 +/- 3%体重减轻）和61名肥胖受试者在胃旁路手术前和手术后2年（33 +/- 9%体重减轻）。根据脂肪细胞体积和总脂肪量之间的关系，计算每个个体的脂肪组织肥大或增生程度（称为形态值）。胰岛素敏感性采用稳态模型评估-估计胰岛素抵抗（HOMA（IR））。结果：在两个队列中，基线时肥大组空腹血浆胰岛素和HOMAIR值均显著高于增生组（P
BACKGROUND: Cross-sectional studies show that white adipose tissue hypertrophy (few, large adipocytes), in contrast to hyperplasia (many, small adipocytes), associates with insulin resistance and increased risk of developing type 2 diabetes. We investigated if baseline adipose cellularity could predict improvements in insulin sensitivity following weight loss.METHODS: Plasma samples and subcutaneous abdominal adipose biopsies were examined in 100 overweight or obese individuals before and 10 weeks after a hypocaloric diet (7 +/- 3% weight loss) and in 61 obese subjects before and 2 years after gastric by-pass surgery (33 +/- 9% weight loss). The degree of adipose tissue hypertrophy or hyperplasia (termed the morphology value) in each individual was calculated on the basis of the relationship between fat cell volume and total fat mass. Insulin sensitivity was determined by homeostasis model assessment-estimated insulin resistance (HOMA(IR)).RESULTS: In both cohorts at baseline, subjects with hypertrophy displayed significantly higher fasting plasma insulin and HOMAIR values than subjects with hyperplasia (P