Probiotics in the gastrointestinal diseases of the elderly
Probiotics in the gastrointestinal diseases of the elderly
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DOI：
10.1007/s12603-011-0357-1
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发表时间：
2012-04-01
影响因子：
5.8
通讯作者：
Salmeri, M.
中科院分区：
文献类型：
--
作者：
Malaguarnera, G.;Leggio, F.;Salmeri, M.
老年人肠道菌群的变化似乎涉及健康细菌（乳酸杆菌和双歧杆菌）数量的减少和潜在致病菌数量的增加。这些变化通常被描述为胃肠道疾病和感染。本文分析了益生菌对老年人的益处，特别是与老年人相关的最新研究，例如检查肠道感染、腹泻相关性腹泻和艰难梭菌相关性腹泻、功能性肠道问题（便秘和肠易激综合征）、炎症性肠病、刺激免疫系统和预防癌症的试验。越来越多的研究表明，一些益生菌菌株可能有助于维持老年人的健康，这表明提供发酵乳制品既有益于健康又节省成本。这些好处包括：建立平衡的肠道微生物群落;改善定植抗性和/或预防腹泻;减少粪便酶;减少血清胆固醇;减少潜在的诱变剂;减少乳糖不耐受;合成维生素;预消化蛋白质。
Changes of the gut microflora in elderly appear to involve a reduction in numbers of healthy bacteria (lactobacilli and bifidobacteria) and an increase in numbers of potentially pathogenic species. These changes are generally described as gastrointestinal disorders and infections. This review analyses benefits of probiotics in old people, with particular interesting for the latest researches relevant to elderly people, e.g. trials examining enteric infections, antibiotic-associated diarrhea and Clostridium difficile associated diarrhea, functional bowel problems (constipation and irritable bowel syndrome), inflammatory bowel diseases, stimulation of the immune system and prevention of cancer. A growing number of researches indicates that some probiotic strains may help to maintain the health in old people, suggesting both health and cost-saving benefits in offering fermented dairy products. These benefits include: establishment of balanced intestinal microflora; improving colonization resistance and or prevention of diarrhea; reduction of fecal enzymes; reduction of serum cholesterol; reduction of potential mutagenes; reduction of lactose intolerance; synthesis of vitamins; predigestion of proteins.