The load and distribution of β-amyloid in brain tissue of patients with Alzheimer's disease
The load and distribution of β-amyloid in brain tissue of patients with Alzheimer's disease
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DOI：
10.1034/j.1600-0404.2001.103002088.x
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发表时间：
2001-02-01
影响因子：
3.5
通讯作者：
Alafuzoff, I
中科院分区：
文献类型：
--
作者：
Kraszpulski, M;Soininen, H;Alafuzoff, I
最近的发现强调了β-淀粉样蛋白(βA4)在阿尔茨海默病(AD)病因中的重要性。在60例AD患者中，应用免疫组织化学技术估计的βA4沉积量受到载脂蛋白E(ApoE)基因(epsilon4/epsilon4>；epsilon4/x>；x/x)、发病年龄(老年前期)、死亡年龄(年轻患者)和病程(短)的显著影响。形态计量学分析显示，βA4负荷在皮质浅层最高，对垂直分布有显著影响的是女性而不是男性，家族性而不是散发性病例，老年而不是老年前期病例。我们的研究结果表明，ApoE基因和性别等危险因素不仅影响BA4的负荷，而且影响BA4在皮质内的垂直分布。
Recent findings have underlined the significance of beta -amyloid protein (beta A4) in the etiology of Alzheimer's disease (AD). In 60 patients with AD, the amount of beta A4 deposition, estimated applying immunohistochemical techniques, was shown to be significantly influenced by apolipoprotein E (ApoE) genotype (epsilon4/epsilon4 >epsilon4/x > x/x), by the age at onset (presenile > senile), by the age at death (younger > older patients) and by the duration of the disease (long > short). Morphometric analysis revealed that the beta A4 load was highest in the superficial layer of the cortex and a significant influence on the vertical distribution was seen in females but not in males, in familial but not in sporadic cases and in senile but not in presenile cases. Our findings indicate that not only the load but also the vertical distribution of beta A4 within cortex is influenced by risk factors such as ApoE genotype and gender.