Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema.
Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema.
复制标题
肺纤维化和肺气肿的患者肺组织中的炎症特征。
DOI：
10.1080/1354750x.2018.1542458
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发表时间：
2019-05
期刊：
影响因子：
--
通讯作者：
Criner GJ
中科院分区：
文献类型：
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作者：
Cornwell WD;Kim C;Lastra AC;Dass C;Bolla S;Wang H;Zhao H;Ramsey FV;Marchetti N;Rogers TJ;Criner GJ
目前，合并肺纤维化和肺气肿(CPFE)的病因和炎症特征仍不确定。我们的目标是检测一组肺气肿、间质性肺纤维化(IPF)和CPFE患者肺组织中炎性蛋白的水平。取肺气肿、IPF、CPFE患者(或正常人)的移植肺，制备组织提取液。在每个组织切片中测量了34种炎性蛋白。与CPFE组织相比，IPF组织中所有34种蛋白的表达水平几乎是不可区分的，而肺气肿组织中的炎症特征与IPF和CPFE组织中的炎症特征是不同的。此外，炎症蛋白水平与病变组织水平的严重程度无关。我们发现，与IPF或CPFE相比，肺气肿肺组织具有不同的炎症特征。然而，CPFE肺的炎症特征与IPF患者的肺本质上是相同的。这些数据表明，与IPF和CPFE相比，不同的炎症过程共同促进了肺气肿患者的疾病过程。
The etiology and inflammatory profile of combined pulmonary fibrosis and emphysema (CPFE) remain uncertain currently. We aimed to examine the levels of inflammatory proteins in lung tissue in a cohort of patients with emphysema, interstitial pulmonary fibrosis (IPF), and CPFE. Explanted lungs were obtained from subjects with emphysema, IPF, CPFE, (or normal subjects), and tissue extracts were prepared. Thirty-four inflammatory proteins were measured in each tissue section. The levels of all 34 proteins were virtually indistinguishable in IPF compared with CPFE tissues, and collectively the inflammatory profile in the emphysematous tissues were distinct from IPF and CPFE. Moreover, inflammatory protein levels were independent of the severity of the level of diseased tissue. We find that emphysematous lung tissues have a distinct inflammatory profile compared with either IPF or CPFE. However, the inflammatory profile in CPFE lungs is essentially identical to lungs from patients with IPF. These data suggest that distinct inflammatory processes collectively contribute to the disease processes in patients with emphysema, when compared to IPF and CPFE.