Acute chest pain in a patient treated with capecitabine
Acute chest pain in a patient treated with capecitabine
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DOI：
10.1007/bf03086268
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发表时间：
2009-08-01
影响因子：
2
通讯作者：
Bosker, H. A.
中科院分区：
文献类型：
--
作者：
Camaro, C.;Danse, P. W.;Bosker, H. A.
一名61岁男性，有转移性结直肠癌病史，因急性ST段抬高型心肌梗死转诊至我院进行初次冠状动脉介入治疗。然而，冠状动脉造影未发现明显狭窄。当被问及时，患者透露，他的肿瘤科医生在入院前一天开始使用卡培他滨（Xeloda (R)）。据了解，这种口服5-FU类似药物用于治疗转移性结直肠癌，可引起冠状动脉痉挛。卡培他滨引起的血管痉挛的主要治疗方法是停药。事实上，停药后，患者没有出现任何症状，心电图异常也恢复正常。 （《内斯心脏杂志》2009 年；17：288-91。）
A 61-year-old male with a history of metastatic colorectal cancer was referred to our hospital for primary coronary intervention because of acute ST-elevation myocardial infarction. Coronary angiography, however, revealed no significant stenoses. When asked, the patient revealed that capecitabine (Xeloda (R)) was started by his oncologist one day before admission. It is known that this oral 5-FU analogue drug, used in metastatic colorectal cancer, can cause coronary artery spasms. The main treatment of capecitabine-induced vasospasm is discontinuation of the drug. Indeed, after cessation of the drug the patient remained free of symptoms and the ECG abnormalities normalised. (Neth Heart J 2009;17:288-91.)