The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain
The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain
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DOI：
10.1016/s0014-2999(02)02924-2
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发表时间：
2003-01-24
影响因子：
5
通讯作者：
Jensen, BS
中科院分区：
文献类型：
--
作者：
Blackburn-Munro, G;Jensen, BS
我们在实验性疼痛大鼠模型中测试了抗惊厥药KCNQ通道开启剂N-（2-氨基-4-（4-氟氨基）苯基）氨基乙酯（雷加滨）的抗伤害性作用。在慢性收缩性损伤和神经性疼痛的保留神经模型中，注射瑞gabine（5和20 mg/kg， p.o.）可显著减轻损伤后爪针刺刺激的机械超敏反应（P < 0.05）。相比之下，雷加滨对两种模型损伤后爪对von Frey刺激的机械超敏反应均无影响。对氯乙酯的冷敏感性仅降低(P
We have tested for anti-nociceptive effects of the anticonvulsant KCNQ channel opener, N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester (retigabine), in rat models of experimental pain. In the chronic constriction injury and spared nerve models of neuropathic pain, injection of retigabine (5 and 20 mg/kg, p.o.) significantly attenuated (P < 0.05) mechanical hypersensitivity in response to pin prick stimulation of the injured hindpaw. In contrast, retigabine had no effect on mechanical hypersensitivity to von Frey stimulation of the injured hindpaw in either model. Cold sensitivity in response to ethyl chloride was only attenuated (P