Normal Ovarian Function and Assessment of Ovarian Reserve in the Survivor of Childhood Cancer
Normal Ovarian Function and Assessment of Ovarian Reserve in the Survivor of Childhood Cancer
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DOI：
10.1002/pbc.22012
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发表时间：
2009-08-01
影响因子：
3.2
通讯作者：
Wallace, W. Hamish B.
中科院分区：
文献类型：
--
作者：
Johnston, Robert J.;Wallace, W. Hamish B.
越来越多的年轻人在儿童时期就能从癌症中幸存下来，因此，治疗并发症变得越来越普遍和重要。卵巢早衰被认为是放射治疗的并发症，包括盆腔和烷化剂为基础的化疗。青春期前的年轻女孩不受性腺毒性治疗的影响。一个年轻的女性，在儿童时期成功治疗癌症，可能会经历定期的卵巢储备显着减少的存在。然而，没有可靠的措施卵巢储备可用于个别妇女。卵巢功能的评估依赖于使用替代标志物，如卵泡刺激素、B-B和抗苗勒管激素，以及超声评估卵巢体积和窦卵泡计数。我们讨论了正常卵巢功能的生理学，癌症治疗对卵巢功能的影响，以及评估儿童癌症幸存者卵巢储备的技术。儿科血液癌症2009;53：296-302。(C)2009威利-利斯公司
Increasingly young people survive cancer in childhood and as a result complications of its treatment are becoming more common and important. Premature ovarian failure is recognized as a complication of radiotherapy to a field that includes the pelvis and alkylating-agent-based chemotherapy. Young pre-pubertal girls are not protected from the effects of gonadal toxic therapy. A young woman, successfully treated for cancer during childhood, may experience regular periods in the presence of a significantly reduced ovarian reserve. There is, however, no reliable measure of ovarian reserve available for the individual woman. Assessment of ovarian function relies on the use Of Surrogate markers Such as follicle stimulating hormone, inhibin-B, and anti-mullerian hormone as well as ultrasound assessment of ovarian volume and antral follicle count. We discuss the physiology of normal ovarian function, the effects of cancer treatments on ovarian function and the techniques for evaluation of ovarian reserve in survivors of childhood cancer. Pediatr Blood Cancer 2009;53:296-302. (C) 2009 Wiley-Liss, Inc.