Epigenetic priming as a mechanism of predetermination of spermatogonial stem cell fate.
Epigenetic priming as a mechanism of predetermination of spermatogonial stem cell fate.
复制标题
表观遗传启动作为精原干细胞命运预先决定的机制。
DOI：
10.1111/andr.13332
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发表时间：
2023
期刊：
影响因子：
4.5
通讯作者：
McCarrey,JohnR
中科院分区：
文献类型：
--
作者：
McCarrey,JohnR
在发育中的哺乳动物睾丸中，只有一小部分胎儿和新生儿精原细胞产生精原干细胞（SSCs）的基础库。多条证据表明，确定哪些原球茎产生基础SSC不是随机的，而是预先确定的，从而确保基础SSC发展出有利的特征，例如增强的遗传完整性。在这里，我认为，差异表观遗传编程有助于分子机制，发展中的早期亚群的胚胎干细胞成为预定的基础池形成的。这将包括表观遗传编程，促进发展有利特征所需的基因的积极表达，以及差异表观遗传引发，当基础SSC出现在出生后睾丸中时，标记包含SSC特异性转录组的基因被激活。我建议，在一起，差异表观遗传编程和表观遗传启动有助于分子机制，通过该机制，早期亚群的发育中的精原细胞成为预定的形成基础池的精原细胞。
In the developing mammalian testis, only a small proportion of fetal and neonatal prospermatogonia give rise to the foundational pool of spermatogonial stem cells (SSCs). Multiple lines of evidence have suggested the determination of which prospermatogonia give rise to foundational SSCs is not random, but is rather predetermined, such that foundational SSCs are ensured to develop advantageous characteristics such as enhanced genetic integrity. Here I suggest that differential epigenetic programing contributes to the molecular mechanisms by which an early subset of developing prospermatogonia becomes predetermined to form the foundational pool of SSCs. This would include epigenetic programing that promotes active expression of genes needed to develop advantageous characteristics, as well as differential epigenetic priming, which bookmarks genes that comprise the SSC‐specific transcriptome to become activated when foundational SSCs appear in the postnatal testis. I suggest that, together, differential epigenetic programing and epigenetic priming contribute to the molecular mechanisms by which an early subset of developing prospermatogonia becomes predetermined to form the foundational pool of SSCs.