Hesperidin regresses cardiac hypertrophy by virtue of PPAR-γ agonistic, anti-inflammatory, antiapoptotic, and antioxidant properties
Hesperidin regresses cardiac hypertrophy by virtue of PPAR-γ agonistic, anti-inflammatory, antiapoptotic, and antioxidant properties
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DOI：
10.1002/jbt.22283
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发表时间：
2019-05-01
影响因子：
3.6
通讯作者：
Arya, Dharamvir Singh
中科院分区：
文献类型：
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作者：
Bhargava, Poorva;Verma, Vipin Kumar;Arya, Dharamvir Singh
橙皮苷（HES）是一种主要存在于柑橘类水果中的黄烷酮糖苷，对过氧化物酶体增殖物激活受体γ（PPAR-gamma）具有激动活性。PPAR-gamma是心脏肥大（CH）信号通路的抑制剂。在这项研究中，我们研究了羟乙基淀粉在异丙肾上腺素（ISO）诱导的CH通过PPAR-gamma激动活性的心脏保护作用。为此，将雄性白化病Wistar大鼠分为6组（n = 6），即正常组、ISO对照组、羟乙基淀粉治疗组（200 mg/kg; p.o.）、HES本身（200 mg kg（-1）;口服），依那普利治疗组（30 mg/kg; p.o.），联合组（羟乙基淀粉200 mg/kg; p.o.+依那普利30 mg kg（-1）; p.o.）。ISO（3 mg kg（-1）; s.c.）HES或依那普利治疗28天显著减轻病理变化，改善心脏血流动力学，抑制氧化应激和细胞凋亡，同时沿着增加的PPAR-gamma表达。依那普利联合羟乙基淀粉对上述所有参数的影响与羟乙基淀粉或依那普利单用相似。因此，羟乙基淀粉可作为一种有前途的缓解CH的分子进行进一步评价。
Hesperidin (HES), a flavanone glycoside, predominant in citrus fruits, has an agonistic activity on peroxisome proliferator-activated receptor gamma (PPAR-gamma). PPAR-gamma is an inhibitor of cardiac hypertrophy (CH) signaling pathways. In this study, we investigated the cardioprotective effect of HES in isoproterenol (ISO)-induced CH through PPAR-gamma agonistic activity. For this, male albino Wistar rats were divided into six groups (n = 6), that is, normal, ISO-control, HES treatment group (200 mg kg(-1); p.o.), HES per se (200 mg kg(-1); p.o.), enalapril treatment group (30 mg kg(-1); p.o.), and combination group (HES 200 mg kg(-1); p.o.+enalapril 30 mg kg(-1); p.o.). ISO (3 mg kg(-1); s.c.) was administered to all groups except normal and per se to induce CH. HES or enalapril treatment of 28 days significantly attenuated pathological changes, improved cardiac hemodynamics, suppressed oxidative stress, and apoptosis along with an increased PPAR-gamma expression. The combination of enalapril with HES exhibited an effect similar to that of HES or enalapril alone on all the aforementioned parameters. Therefore, HES may be further evaluated as a promising molecule for the alleviation of CH.