Treatment of primary osteoporosis with fluoride and calcium. Clinical tolerance and fracture occurrence.
Treatment of primary osteoporosis with fluoride and calcium. Clinical tolerance and fracture occurrence.
复制标题
用氟化物和钙治疗原发性骨质疏松症。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
Donald R. Taves
中科院分区：
文献类型：
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作者：
B. Riggs;Stephen F. Hodgson;David L. Hoffman;Patrick J. Kelly;Kenneth A. Johnson;Donald R. Taves
36名原发性骨质疏松症患者接受了长达6年的氟化钠、钙补充剂治疗，24名患者接受了维生素D治疗。15名患者（42%）发生了主要不良反应（滑膜炎、疼痛性足底筋膜综合征、复发性呕吐或贫血）。新的椎骨骨折发生率为每1,000年观察329例骨折。其中近一半发生在治疗的第一年，而在12例椎体X线片显示氟诱导小梁形成增加的患者中，发生率仅为六分之一。然而，在长期安全性和抗骨折疗效得到更好的确定之前，该方案应继续限于研究使用。
Thirty-six patients with primary osteoporosis were treated for up to six years with sodium fluoride, calcium supplements, and, in 24 patients, vitamin D. Major adverse reactions (synovitis, painful plantar fascial syndrome, recurrent vomiting, or anemia) occurred in 15 patients (42%). New vertebral fractures occurred at a rate of 329 fractures per 1,000 years of observation. Almost half of them occurred during the first year of therapy, and they were only one sixth as frequent in 12 patients who had fluoride-induced increased trabeculation on vertebral roentogenograms. Nevertheless, until long-term safety and antifracture efficacy are better established, this regimen should continue to be restricted to investigational use.