Early changes in prefrontal activity characterize clinical responders to antidepressants
Early changes in prefrontal activity characterize clinical responders to antidepressants
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DOI：
10.1016/s0893-133x(02)00294-4
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发表时间：
2002-07-01
影响因子：
7.6
通讯作者：
Uijtdehaage, SHJ
中科院分区：
文献类型：
--
作者：
Cook, IA;Leuchter, AF;Uijtdehaage, SHJ
以前的研究表明，大脑功能的变化先于抗抑郁药物的临床反应。在这里，我们研究了定量脑电图（QEEG）的绝对和相对功率和一个新的措施，cordance，用于检测与治疗反应相关的区域变化。51名患有单相抑郁症的成年人完成了使用氟西汀或文拉法辛与安慰剂的治疗试验。在基线和药物或安慰剂治疗48小时和1周后记录数据。在四个受试者组（药物和安慰剂应答者和无应答者）中检查特定脑区的基线值和较基线值的变化。各组之间没有发现区域基线QEEG差异;随着时间的推移，θ功率也没有显著变化。相比之下，药物反应者在48小时和1周时表现出独特的前额叶皮质的显著降低，直到四周后才出现临床差异。这些发现暗示了前额区在介导抗抑郁药物反应中的作用。一致性可能具有临床适用性，可作为个体反应的主要指标。(C)2002年美国神经精神药理学学会。出版社：Elsevier Science Inc.
Previous studies have shown that changes in brain function precede clinical response to antidepressant medications. Here we examined quantitative EEG (QEEG) absolute and relative power and a new measure, cordance, for detecting regional changes associated with treatment response. Fifty-one adults with unipolar depression completed treatment trials using either fluoxetine or venlafaxine vs. placebo. Data were recorded at baseline and after 48 h and 1 week on drug or placebo. Baseline and change from baseline values were examined for specific brain regions in four subject groups (medication and placebo responders and nonresponders). No regional baseline QEEG differences were found among the groups; there also were no significant changes in theta power over time. In contrast, medication responders uniquely showed significant decreases in prefrontal cordance at 48 h and I week, Clinical differences did not emerge until after four weeks. Subjects with greater changes in cordance had the most complete 8-week responses, These findings implicate the prefrontal region in mediating response to antidepressant medications. Cordance may have clinical applicability as a leading indicator of individual response. (C) 2002 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.