IRON-DEFICIENCY AND ANEMIA OF CHRONIC DISEASE IN ELDERLY WOMEN - A DISCRIMINANT-ANALYSIS APPROACH FOR DIFFERENTIATION
IRON-DEFICIENCY AND ANEMIA OF CHRONIC DISEASE IN ELDERLY WOMEN - A DISCRIMINANT-ANALYSIS APPROACH FOR DIFFERENTIATION
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DOI：
10.1093/ajcn/61.3.590
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发表时间：
1995-03-01
影响因子：
7.1
通讯作者：
HALEY, NR
中科院分区：
文献类型：
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作者：
AHLUWALIA, N;LAMMIKEEFE, CJ;HALEY, NR
为了区分老年妇女缺铁性贫血和慢性炎症性疾病相关性贫血，通过判别分析获得实验室、饮食和功能评估变量的子集。51例受试者（70-79岁）根据是否存在缺铁和慢性炎症性疾病分为四组。铁缺乏是根据铁补充后血红蛋白浓度的显著反应来定义的。实验室检查的区分子集包括血清铁蛋白、血浆转铁蛋白受体和红细胞沉降率的测量。判别函数将受试者分为缺铁、慢性病贫血或两者共存的类别，错误率为18.6%。添加其他变量（膳食铁和功能评估信息）并没有明显改善分类。这三个关键实验室测试的结果可能有助于识别慢性炎症存在下的功能性缺铁。
To differentiate iron-deficiency anemia and anemia associated with chronic inflammatory diseases in elderly women, subsets of laboratory, dietary, and functional assessment variables were obtained by using discriminant analysis. Fifty-one subjects (70-79 y of age) were classified into one of four groups on the basis of the presence of iron deficiency and chronic inflammatory disease. Iron deficiency was defined on the basis of a significant response in hemoglobin concentration after iron supplementation. The discriminating subset of laboratory tests consisted of measures for serum ferritin, plasma transferrin receptors, and erythrocyte sedimentation rate. The discriminant function classified subjects into iron-deficient, anemia of chronic disease, or a category in which the two coexist, with an error rate of 18.6%. The addition of other variables (dietary iron and functional assessment information) did not appreciably improve the classification. The results of these three key laboratory tests may help to identify functional iron deficiency in the presence of chronic inflammation.