Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication
Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication
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DOI：
10.1016/s0028-3932(99)00103-7
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发表时间：
2000-01-01
期刊：
影响因子：
2.6
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Swainson, R;Rogers, RD;Robbins, TW
将三组帕金森病 (PD) 患者（轻度未用药 (UPD)、轻度用药 (MPD) 和重度用药 (SPT)）以及额叶 (FLL) 或颞叶 (TLL) 损伤的患者与匹配对照的概率 ic 和两对并发颜色辨别的学习和逆转进行比较。两个皮质损伤组都表现出逆转缺陷，持续反应没有增加。 UPD组虽然在空间识别任务上受损，但表现出完整的辨别学习和逆转能力； MPD 和 SPD 患者在两项逆转任务上均表现出非持续性逆转损伤。基于疾病严重程度和药物可能产生的有害作用，提出了两种假设来解释 PD 患者的逆转损伤，并根据多巴胺在基于奖励的学习中的作用来讨论结果。 (C) 2000 Elsevier Science Ltd. 保留所有权利。
Three groups of patients with Parkinson's disease (PD) - mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPT) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic ic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recognition task, showed intact discrimination learning and reversal; the MPD and SPD patients showed non-perseverative reversal impairments on both reversal tasks. Two hypotheses - based on disease severity and possible deleterious effects of medication - are offered to explain the reversal impairments of the PD patients and the results are discussed in terms of the role of dopamine in reward-based learning. (C) 2000 Elsevier Science Ltd. All rights reserved.