Replacement of progesterone restores the nocturnal surge of prolactin following suppression with a gonadotropin-releasing hormone agonist during early pregnancy in the rat.
Replacement of progesterone restores the nocturnal surge of prolactin following suppression with a gonadotropin-releasing hormone agonist during early pregnancy in the rat.
复制标题
在大鼠妊娠早期，用促性腺激素释放激素激动剂抑制后，补充黄体酮可恢复催乳素夜间激增的情况。
DOI：
10.1016/0024-3205(91)90212-t
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发表时间：
1991
期刊：
影响因子：
6.1
通讯作者：
Sridaran,R
中科院分区：
文献类型：
--
作者：
Joseph,IB;Sridaran,R
从妊娠第7天开始，以5 μg/天的剂量连续给予GnRH激动剂（GnRH-Ag），导致第8天催乳素（PRL）的每日夜间激增和随后终止妊娠的血清孕酮（P4）水平受到抑制。以4 mg/天s.c.的剂量，用P4的合成类似物dydrogestrin替代。恢复了夜间催乳素激增的幅度这些数据表明，GnRH-Ag可能在大脑水平抑制夜间PRL激增，导致血清P4水平下降，或在黄体本身水平或同时在两个部位终止妊娠。
Continuous administration of a GnRH agonist (GnRH-Ag) at a dose of 5 μg/day, commencing on day 7 of pregnancy resulted in the suppression of daily nocturnal surges of prolactin (PRL) on day 8, and serum progesterone (P4) levels with subsequent termination of pregnancy. Replacement with dydrogesterone, a synthetic analog of P4at a dose of 4 mg/day s.c. restored the magnitude of nocturnal PRL surges. These data suggest that GnRH-Ag may act either at the level of the brain to suppress the nocturnal PRL surge, resulting in a fall in serum P4levels or at the level of the corpus luteum itself or at both sites simultaneously to terminate pregnancy.