Intravenous hemostat: nanotechnology to halt bleeding.
Intravenous hemostat: nanotechnology to halt bleeding.
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DOI：
10.1126/scitranslmed.3000397
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发表时间：
2009-12-16
影响因子：
17.1
通讯作者：
Lavik EB
中科院分区：
文献类型：
--
作者：
Bertram JP;Williams CA;Robinson R;Segal SS;Flynn NT;Lavik EB
失血是平民和战场创伤死亡的主要原因。止血的方法包括加压敷料和吸收材料。例如，快速凝块通过吸收大量液体和浓缩血小板以增强凝血来有效地停止出血，但这些治疗仅限于可压缩和暴露的伤口。理想的治疗方法是仅在受伤部位止血，在室温下稳定，易于管理，对内伤有效。我们已经开发了基于Arg-Gly-Asp功能化纳米颗粒的合成血小板，在严重创伤的大鼠模型中静脉给药后，其出血时间减半。这些合成血小板的效果超过了其他治疗方法，包括临床上用于不受控制的出血的重组因子VIIa。在20 mg/ml的剂量下，合成血小板在24小时内被清除，并且在输注后7天（研究的最长时间点）内未观察到并发症。这些合成血小板可能有助于创伤的早期干预，并证明了纳米技术在解决未满足的医疗需求方面的作用。
Blood loss is the major cause of death in both civilian and battlefield traumas. Methods to staunch bleeding include pressure dressings and absorbent materials. For example, Quik-clot effectively halts bleeding by absorbing large quantities of fluid and concentrating platelets to augment clotting, but these treatments are limited to compressible and exposed wounds. An ideal treatment would halt bleeding only at the injury site, be stable at room temperature, be administered easily, and work effectively for internal injuries. We have developed synthetic platelets, based on Arg-Gly-Asp functionalized nanoparticles, that halve bleeding time after intravenous administration in a rat model of major trauma. The effects of these synthetic platelets surpass other treatments including recombinant factor VIIa, which is used clinically for uncontrolled bleeding. Synthetic platelets were cleared within 24 hours at a dose of 20 mg/ml, and no complications were seen out to 7 days after infusion, the longest time point studied. These synthetic platelets may be useful for early intervention in trauma and demonstrate the role that nanotechnology can have in addressing unmet medical needs.
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影响因子：
14
作者：
Ebara, Mitsuhiro;Yamato, Masayuki;Okano, Teruo
通讯作者：
Okano, Teruo
DOI：
10.1097/01.ta.0000057151.02906.27
发表时间：
2003-05-01
影响因子：
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作者：
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通讯作者：
Leppaniemi, A
影响因子：
3.5
作者：
Boxus, T;Touillaux, R;Marchand-Brynaert, J
通讯作者：
Marchand-Brynaert, J
DOI：
10.1081/bio-120023155
发表时间：
2003-01-01
影响因子：
--
作者：
Chang, TMS;Powanda, D
通讯作者：
Powanda, D
影响因子：
4.7
作者：
Okamura, Yosuke;Fukui, Yoshihito;Takeoka, Shinji
通讯作者：
Takeoka, Shinji