A BROADENED SPECTRUM OF JUVENILE MYOSITIS - MYOSITIS-SPECIFIC AUTOANTIBODIES IN CHILDREN
A BROADENED SPECTRUM OF JUVENILE MYOSITIS - MYOSITIS-SPECIFIC AUTOANTIBODIES IN CHILDREN
复制标题
DOI：
10.1002/art.1780371019
复制
发表时间：
1994-10-01
影响因子：
--
通讯作者：
PLOTZ, PH
中科院分区：
文献类型：
--
作者：
RIDER, LG;MILLER, FW;PLOTZ, PH
Objective.肌炎特异性自身抗体（MSA）在特发性炎性肌病（IIM）成人中定义了相对同质的临床和免疫遗传学患者群体。本研究探讨MSA在定义肌炎儿童组中的有用性。采用免疫沉淀法和免疫扩散法对77例肌炎和其它结缔组织病患儿血清进行了MSA检测。收集临床资料并进行分析。MSA抗PL-12（丙氨酰转移RNA合成酶），抗Jo-1（组氨酰-tRNA合成酶），抗信号识别颗粒和抗Mi-2分别在12名IIM儿童的血清中鉴定。在这些患者中，临床表现、病程和治疗反应与具有相同自身抗体的成人患者非常相似。这些观察结果表明，由特定MSA定义的临床综合征在IIM儿童和成人中是相似的。通过定义患有MSA的儿童的类似临床综合征，本研究为未来MSA在儿童特发性炎性肌病中的研究提供了基础，这可能有助于预测这些患者的一个子集的临床病程并改善其治疗。
Objective. Myositis-specific autoantibodies (MSA) define relatively homogenous clinical and immunogenetic patient groups in adults with idiopathic inflammatory myopathies (IIM). This study explores the usefulness of MSA in defining groups of children with myositis.Methods. Sera from 77 children with myositis and other connective tissue diseases were tested for MSA by immunoprecipitation and immunodiffusion. Clinical data were collected and analyzed.Results. The MSA anti-PL-12 (alanyl-transfer RNA synthetase), anti-Jo-1 (histidyl-tRNA synthetase), anti-signal recognition particle, and anti-Mi-2 were each identified in the sera of 12 children with IIM. In these patients, the clinical manifestations, disease courses, and responses to therapy closely resembled those in adults with the same autoantibodies.Conclusion. These observations suggest that the clinical syndromes defined by particular MSA are similar in children and adults with IIM. By defining similar clinical syndromes in children who have MSA, this study provides a basis for future studies of MSA in the idiopathic inflammatory myopathies of childhood, which may be useful in predicting the clinical courses of a subset of these patients and improving their therapy.