The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer
The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer
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DOI：
10.1158/1055-9965.epi-04-0490
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发表时间：
2005-02-01
影响因子：
3.8
通讯作者：
Boyd, N
中科院分区：
文献类型：
--
作者：
Li, T;Sun, LM;Boyd, N
背景：我们使用在法医尸检中获得的、没有选择是否存在异常的乳腺组织，研究了乳腺组织的测量特性与乳房X线摄影密度和其他乳腺癌危险因素之间的关系。方法：我们从S.C.在法医尸检时切除乳房，用定量显微镜测量组织学特征。确定活检组织中细胞(以核面积估算)、腺体结构和胶原蛋白的比例。这些测量结果与活检组织切片的Faxitron图像中的百分比密度以及乳腺癌的其他危险因素有关。结果：乳腺X线摄影的百分比密度与活检组织中上皮核和非上皮核所占面积的比例、胶原蛋白和腺体结构的面积有关。乳腺癌的其他几个危险因素，包括体重、产次、出生人数和绝经状况，与乳腺摄影密度的变化有关，也与这些组织特征中的一个或多个特征的差异有关。结论：所有乳腺癌危险因素最终都必须通过对乳房的影响来发挥其影响，这些发现表明，对于一些风险因素，这种影响包括对细胞数量和胶原蛋白数量的影响。
Background: We have examined the relationships between the measured properties of breast tissue and mammographic density and other risk factors for breast cancer, using breast tissue obtained at forensic autopsy and not selected for the presence of abnormalities.Methods: We used randomly selected tissue blocks taken from breast tissue slices obtained by s.c. mastectomy at the time of forensic autopsy to measure histologic features using quantitative microscopy. The proportions of the biopsy occupied by cells (estimated by nuclear area), glandular structures, and collagen were determined. These measurements were examined in relation to the percent density in the faxitron image of the tissue slice from which the biopsy was taken and other risk factors for breast cancer.Results: The percent mammographic density was associated with the proportion of the area of the biopsy occupied by nuclei, both epithelial and nonepithelial, and by collagen and the area of glandular structures. Several other risk factors for breast cancer, notably body weight, parity, and number of births, and menopausal status, that are associated with variations in mammographic density, were also associated with differences in one or more of these tissue features.Conclusion: All risk factors for breast cancer must ultimately exert their influence by an effect on the breast, and these findings suggest that, for some risk factors, this influence includes an effect on the number of cells and the quantity of collagen.