Physiologic characterisation of glioblastoma multiforme using MRI-based hypoxia mapping, chemical shift imaging, perfusion and diffusion maps.
Physiologic characterisation of glioblastoma multiforme using MRI-based hypoxia mapping, chemical shift imaging, perfusion and diffusion maps.
复制标题
使用基于 MRI 的缺氧图、化学位移成像、灌注和扩散图对多形性胶质母细胞瘤进行生理表征。
DOI：
10.1016/j.jocn.2005.12.025
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Meyerand,MElizabeth
中科院分区：
文献类型：
--
作者：
McMillan,KathrynM;Rogers,BaxterP;Field,AaronS;Laird,AngelaR;Fine,JasonP;Meyerand,MElizabeth
多参数、生理MRI方法被认为是更完整的脑活检证实的多形性胶质母细胞瘤（GBM）。化学位移成像（CSI）提供了代谢物比例的生化信息，而灌注图像提供了来自局部脑血容量（rCBV）和渗透性图的假定血管分布数据。扩散加权图像被减少到表观扩散系数（ADC）地图，以评估cellularity，和血氧水平依赖性成像被用来创建地图推定缺氧regions.METHODSSix治疗后GBM患者进行扫描，直到复发的建议，在3个月的时间间隔，由常规MRI参数，产生20扫描考虑。测量每种技术中与其他参数重叠的极端值的百分比，并在半球之间进行比较，以评估utility.TFTSWe发现在选择患病半球的总体重叠百分比时，与来自个体阈值参数图的体素计数相比，性能显着更好。参数选择的基础上，最高的重叠，相应的复合重叠地图显示增加特异性可能复发的地区，通过减少假阳性体素的数量，并提供洞察各种参数之间的关系。CONCLUSION在一个试点组的患者，重叠百分比似乎是敏感的复发性疾病。当用于联合收割机组合多个参数时，包含重叠的体素可以具体地针对可能的复发区域。
PURPOSEA multiparametric, physiologic MRI approach was considered to more completely characterise biopsy-confirmed glioblastoma multiforme (GBM). Chemical shift imaging (CSI) supplied biochemical information in metabolite ratios, while perfusion images provided data on presumed vascularity from regional cerebral blood volume (rCBV) and permeability maps. Diffusion-weighted images were reduced to apparent diffusion coefficient (ADC) maps to evaluate cellularity, and blood oxygen level-dependent imaging was used to create maps of putative hypoxic regions.METHODSSix post-treatment GBM patients were scanned at 3-month intervals until recurrence was suggested by conventional MRI parameters, yielding 20 scans for consideration. The percentage of extreme values in each technique that overlapped with other parameters was measured and compared across hemispheres to assess utility.RESULTSWe found significantly better performance in selecting the diseased hemisphere for overall percent overlap when compared to voxel counts from individual thresholded parameter maps. Parameters were selected on the basis of highest overlap, and corresponding composite overlap maps show increased specificity to likely recurrent regions by reducing the number of falsely positive voxels, and offer insight into relationships between various parameters.CONCLUSIONIn a pilot group of patients, percent overlap appears to be sensitive to recurrent disease. When used to combine multiple parameters, voxels containing overlap can specifically target probable recurrent areas.