Normal retinal vasculature despite familial protein C deficiency.
Normal retinal vasculature despite familial protein C deficiency.
复制标题
尽管存在家族性蛋白 C 缺乏，但视网膜血管系统正常。
DOI：
10.1016/j.ajo.2004.11.036
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Weissgold,DavidJ
中科院分区：
文献类型：
--
作者：
Vossen,CarlaY;Naud,Shelly;Bovill,EdwinG;Weissgold,DavidJ
PURPOSEIt is unclear whether protein C deficiency is associated with retinal venous occlusive disease.DESIGNWe performed a cross-sectional study.METHODSMembers of a protein C-deficient family, either deficient or nondeficient, with a history of nonocular venous thrombosis were included. All participants completed questionnaires regarding their medical and ophthalmic histories. Each subject underwent dilated direct ophthalmoscopic and binocular indirect ophthalmoscopic examinations by a single vitreoretinal specialist.RESULTSNone of the 18 family members with a known history of nonocular thrombosis—12 with and 6 without protein C deficiency— manifested stigmas of recent or chronic retinal vascular occlusive disease.CONCLUSIONSThis study showed no evidence of involvement of the retinal vascular bed in a family with an increased risk of nonocular venous thrombosis attributable to the deficiency of protein C.
