EFFECT OF LUGOL IODINE ON THE VASCULARITY OF THYROID-GLAND IN HYPERTHYROIDISM
EFFECT OF LUGOL IODINE ON THE VASCULARITY OF THYROID-GLAND IN HYPERTHYROIDISM
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DOI：
10.1097/00006231-198909000-00007
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发表时间：
1989-09-01
影响因子：
1.5
通讯作者：
KAPOOR, MM
中科院分区：
文献类型：
--
作者：
RANGASWAMY, M;PADHY, AK;KAPOOR, MM
本文用一种新的客观指标--甲状腺血管指数（TVI），测定了20例甲亢患者（包括Graves病和结节性甲状腺肿）和8例正常人的甲状腺血管。通过比较标准化甲状腺和颈动脉曲线下的面积，直至放射性团首次通过引起的动脉曲线峰值时间，计算TVI。与正常甲状腺相比，所有毒性甲状腺肿都有所增加。TVI（p< 0.001），Graves病最高（p< 0.05）。Graves病的TVI不受卡比马唑治疗的影响，但在加用卢戈碘两周后，10名患者中有8名患者的TVI显著下降（p< 0.01）。在所有10名接受慢性碘治疗长达6周的患者中，TVI持续下降（p< 0.001），无任何激素逃逸。结节性甲状腺肿的TVI在卡比马唑或碘治疗后无明显变化。
Vascularity of the thyroid gland was measured in twenty thyrotoxic patients (including Graves and multinodular goitres) and eight normal subjects by a new objective parameter–Thyroid Vascularity Index'(TVI). The TVI was calculated by comparing the areas under the normalized thyroid and carotid artery curves up to the time of peak of the arterial curve caused by the first passage of a radioactive bolus. Compared to normal thyroid, all the toxic goitres had increased. TVI (p< 0.001); it being maximum in Graves disease (p< 0.05). TVI in Graves disease was not affected by carbimazole therapy but decreased dramatically in eight out of ten patients (p< 0.01) two weeks after Lugol's iodine was added. There was a sustained fall in TVI in all the ten patients (p< 0.001) with chronic iodine therapy up to six weeks without any hormonal escape. TVI in multinodular goitres showed no significance change with carbimazoleor iodine therapy.