Comparison of long-term follow-up of electrocardiographic features in Brugada syndrome between the SCN5A-positive probands and the SCN5A-negative probands
Comparison of long-term follow-up of electrocardiographic features in Brugada syndrome between the SCN5A-positive probands and the SCN5A-negative probands
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DOI：
10.1016/j.amjcard.2007.03.078
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发表时间：
2007-08-15
影响因子：
2.8
通讯作者：
Shimizu, Wataru
中科院分区：
文献类型：
--
作者：
Yokokawa, Miki;Noda, Takashi;Shimizu, Wataru
为了研究Brugada综合征（BS）先证者心电图参数随年龄的变化及其与SCN 5A突变的关系，我们在长期随访中前瞻性地测量了几项心电图参数8例SCN 5A突变的BS先证者（10 +/- 5岁）（SCN 5A阳性组，所有男性;年龄46 +/- 10岁）和36例无SCN 5A突变的BS先证者（SCN 5A阴性组，所有男性;年龄46 +/- 13岁）。在整个随访期间，SCN 5A阳性组的除极参数，如P波（II导联）、QRS（II、V-2、V-5导联）、S波持续时间（II、V-5导联）和PQ间期（II导联）均显著长于SCN 5A阴性组，S波振幅（II、V-5）显著深于SCN 5A阴性组。与SCN 5A阴性组相比，SCN 5A阳性组的校正QT间期（V2导联）显著延长，ST振幅（V-2导联）显著升高。在随访期间，两组的去极化参数均随年龄增长而增加;然而，与SCN 5A阴性组相比，SCN 5A阳性组的PQ间期（II导联）和QRS时限（V-2导联）随年龄增长而延长更显著，QRS轴向左偏移更多。总之，传导减慢更显着，更逐步加重Brugada先证者与SCN 5A突变比那些没有SCN 5A突变。(c)2007年爱思唯尔公司All rights reserved.
To investigate changes of electrocardiographic parameters with aging and their relation to the presence of SCN5A mutation in probands with Brugada syndrome (BS), we measured several electrocardiographic parameters prospectively during long-term follow-up (10 +/- 5 years) in 8 BS probands with SCN5A mutation (SCN5A-positive group, all men; age 46 +/- 10 years) and 36 BS probands without SCN5A mutation (SCN5A-negative group, all men; age 46 +/- 13 years). Throughout the follow-up period, depolarization parameters, such as P-wave (lead II), QRS (leads II, V-2, V-5), S-wave durations (leads II, V-5), and PQ interval (leads II) were all significantly longer and S-wave amplitude (II, V-5) was significantly deeper in the SCN5A-positive group than in the SCN5A-negative group. The SCN5A-positive group showed a significantly longer corrected QT interval (lead V2) and higher ST amplitude (lead V-2) than those in the SCN5A-negative group. The depolarization parameters increased with aging during the follow-up period in both groups; however, the PQ interval (lead II) and QRS duration (lead V-2) were prolonged more prominently and the QRS axis deviated more to the left with aging in the SCN5A-positive group than in the SCN5A-negative group. In conclusion, conduction slowing was more marked and more progressively accentuated in Brugada probands with SCN5A mutation than in those without SCN5A mutation. (c) 2007 Elsevier Inc. All rights reserved.