Cycling behavior and memory formation.
Cycling behavior and memory formation.
复制标题
DOI：
10.1523/jneurosci.3353-09.2009
复制
发表时间：
2009-10-14
期刊：
影响因子：
--
通讯作者：
Roman GW
中科院分区：
文献类型：
--
作者：
Gerstner JR;Lyons LC;Wright KP Jr;Loh DH;Rawashdeh O;Eckel-Mahan KL;Roman GW
昼夜节律研究在确定生物钟输出路径上花费了相当大的努力，包括确定生理和行为过程，这些过程显示出一天中显著的时间变化。记忆的形成和巩固是由内源性昼夜节律振荡器塑造的显著过程。迄今为止，很少有关于记忆机制的研究考虑到一天中的时间和生物体的先天活动周期（例如，夜间，白天或黄昏）的潜在混淆效应。下面的研究强调了最近的工作，描述了昼夜节律和记忆形成的这种相互作用，并在2009年神经科学学会年会上的一个小型研讨会上发表。这些研究在多种行为范式和模式生物中阐明了这些时间观察，包括果蝇的嗅觉回避条件反射、海雀的长期敏化、斑马鱼的主动回避条件反射和啮齿类动物的经典恐惧条件反射，表明昼夜节律对记忆行为的影响在物种之间高度保守。也有证据表明，特定循环分子与记忆形成之间存在保守的机制关系，以及这些分子的适当昼夜循环在多大程度上是最佳认知表现所必需的。研究描述了核心时钟基因周期、血管活性肠肽、褪黑激素和cAMP/MAPK （cAMP/丝裂原活化蛋白激酶）级联的参与。最后，对人类的研究描述了基于睡眠-觉醒稳态和内部生物钟之间相互作用的认知表现改变的证据。昼夜节律与跨物种学习和记忆形成之间的功能关系的保存为未来分析复杂行为背后的分子机制提供了一个关键框架。
Circadian research has spent considerable effort in the determining clock output pathways, including identifying both physiological and behavioral processes that demonstrate significant time-of-day variation. Memory formation and consolidation represent notable processes shaped by endogenous circadian oscillators. To date, very few studies on memory mechanisms have considered potential confounding effects of time-of-day and the organism’s innate activity cycles (e.g., nocturnal, diurnal, or crepuscular). The following studies highlight recent work describing this interactive role of circadian rhythms and memory formation, and were presented at a minisymposium at the 2009 annual meeting of the Society for Neuroscience. The studies illustrate these time-of-day observations in a variety of behavioral paradigms and model organisms, including olfactory avoidance conditioning in Drosophila, long-term sensitization in Aplysia, active-avoidance conditioning in Zebrafish, and classical fear conditioning in rodents, suggesting that the circadian influence on memory behavior is highly conserved across species. Evidence also exists for a conserved mechanistic relationship between specific cycling molecules and memory formation, and the extent to which proper circadian cycling of these molecules is necessary for optimal cognitive performance. Studies describe the involvement of the core clock gene period, as well as vasoactive intestinal peptide, melatonin, and the cAMP/MAPK (cAMP/mitogen-activated protein kinase) cascade. Finally, studies in humans describe evidence for alterations in cognitive performance based on an interaction between sleep–wake homeostasis and the internal circadian clock. Conservation of a functional relationship between circadian rhythms with learning and memory formation across species provides a critical framework for future analysis of molecular mechanisms underlying complex behavior.