ENDOLYMPH FORMATION IN THE INNER-EAR OF PIGEONS
ENDOLYMPH FORMATION IN THE INNER-EAR OF PIGEONS
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DOI：
10.1159/000275899
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发表时间：
1987-01-01
期刊：
影响因子：
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通讯作者：
MORGENSTERN, C
中科院分区：
文献类型：
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作者：
NINOYU, O;HOMMERICH, C;MORGENSTERN, C
本文用双管电极和后置液体离子交换器对家鸽内淋巴间隙进行了研究。内淋巴K ~+活性耳蜗为155 mM，壶腹为133 mM。耳蜗直流电位（+14.5mV）明显低于豚鼠（+ 80 mV），而鸽壶腹直流电位（+7.4mV）是豚鼠（+3.9mV）的2倍。一般应用依他尼酸在鸽子中引起DC电位的微弱变化，并且在耳蜗和壶腹中没有典型的细胞间水肿。局部应用依他尼酸和哇巴因在鸽的耳蜗和壶腹中诱导了-30和-40 mV之间的负DC电位。该负DC电位高于缺氧诱导的负电位。在药物诱导的DC电位过程中短暂缺氧导致DC电位降低至扩散电位以上。在扩散电位以下，额外的缺氧增加了独立于中毒原因的DC电位。
The endolymphatic space of pigeons was studied by using double-barrelled electrodes with a postassium liquid ion exchanger. The K+ activity of the endolymph was 155 mM in the cochlea and 133 mM in the ampulla, respectively Positive DC potential in th cochlea (+ 14.5 mV) was much lower than in guinea pigs (+ 80 mV) whereas in the ampulla of pigeons the DC potential (+ 7.4 mV) was 2 times higher than that of guinea pigs (+ 3.9 mV). General application of ethacrynic acid in pigeons induced a weak change in DC potential and no typical intercellular edema in the cochlea and ampulla. Local application of ethacrynic acid and ouabain in the cochlea and ampulla of pigeons induced a negative DC potential of between - 30 and -40 mV. This negative DC potential was higher than the anoxia-induced negative potential. Short hypoxia during a drug-induced DC potential resulted in a decrease in DC potential above the diffusion potential. Below the diffusion potential additional hypoxia increased the DC potential independent of the cause of intoxication.