Resolution of Cancer-Promoting Inflammation: A New Approach for Anticancer Therapy.
Resolution of Cancer-Promoting Inflammation: A New Approach for Anticancer Therapy.
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解决促癌炎症：抗癌治疗的新方法
DOI：
10.3389/fimmu.2017.00071
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发表时间：
2017
影响因子：
7.3
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Zhang Q;Zhu B;Li Y
炎症是消除有害刺激并恢复组织稳态的保护性反应，而未能解决炎症导致恶性肿瘤的发展。肿瘤炎症微环境中的免疫细胞赋予癌细胞其特定的标志，包括突变、代谢重编程、血管生成、侵袭和转移。用抗炎药物靶向炎症微环境（例如，阿司匹林）或通过增强抗肿瘤免疫（例如，嵌合抗原受体T细胞疗法）已被广泛研究，并在许多癌症中取得了有希望的结果。最近，基于发现有效的内源性特化促消退介质（包括脂氧素、消退素、保护素和maresins），提出了通过双重抗炎和促消退策略促进抗肿瘤免疫的新方法。在这篇综述中，我们描述了炎症消退和癌症免疫的最新主要细胞和分子机制，并讨论了癌症治疗和预防中的促消退策略。
Inflammation is a protective response that eliminates harmful stimuli and restores tissue homeostasis, whereas the failure to resolve inflammation leads to the development of malignancies. Immune cells in the tumor inflammatory microenvironment endow cancer cells with their specific hallmarks, including mutations, metabolic reprograming, angiogenesis, invasion, and metastasis. Targeting the inflammatory microenvironment with anti-inflammatory drugs (e.g., aspirin) or by enhancing antitumor immunity (e.g., chimeric antigen receptor T cell therapy) has been extensively investigated and has achieved promising results in many cancers. Recently, a novel approach promoting antitumor immunity via a dual anti-inflammatory and pro-resolving strategy was proposed based on the discovery of potent, endogenous, specialized pro-resolving mediators, including lipoxins, resolvins, protectins, and maresins. In this review, we describe the updated principal cellular and molecular mechanisms of inflammation resolution and cancer immunity and discuss the pro-resolution strategy in cancer treatment and prevention.