OBSERVATION OF HISTIDINE RESIDUES IN PROTEINS BY MEANS OF NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY
OBSERVATION OF HISTIDINE RESIDUES IN PROTEINS BY MEANS OF NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY
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DOI：
10.1021/ar50086a004
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发表时间：
1975-01-01
影响因子：
18.3
通讯作者：
MARKLEY, JL
中科院分区：
文献类型：
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作者：
MARKLEY, JL
约翰·l·马克里1941年出生于科罗拉多州丹佛市。他在卡尔顿学院获得学士学位，在哈佛大学获得博士学位。他曾在默克研究所担任研究化学家，然后在劳伦斯伯克利实验室与Melvin P. Klein和Melvin Cal-vin一起担任NIH博士后研究员，自1972年以来一直担任普渡大学化学助理教授。主要研究方向为生物大分子，特别是蛋白质的结构和功能。除了研究之外，他还是一名登山运动员和摄影师，并且是锡兰马哈维尔恒河（Mahawell Ganga River）划艇全程的第一批成员。1964年，作为在100兆赫下对蛋白质进行的第一次质子核磁共振研究的一部分，M.曼德尔报告了从核糖核酸酶a的组氨酸残基的咪唑C-2质子中检测到复合信号。
John L. Markley was born In Denver, Colorado, in 1941. He received his BA degree from Carleton College and the Ph. D. from Harvard University. He worked as a research chemist at Merck Institute, then as NIH Postdoctoral Fellow at Lawrence Berkeley Laboratory with Melvin P. Klein and Melvin Cal-vin, and since 1972 has been Assistant Professor of Chemistry at Purdue University. His research Interests largely concern the structure and function of biological macromolecules, especially proteins. Aside from research, he is a mountaineer and a photographer, and was a member of the first party to kayak the length of the Mahawell Ganga River In Ceylon.In 1964, as part of the first proton NMR investiga-tion of proteins at 100 MHz, M. Mandel reported the detection of a composite signal from the imidazole C-2 protons of the histidine residues of ribonuclease A. 2-3 In a prophetic statement, he concluded that,