The oxygen affinity of mammalian hemoglobins in the absence of 2,3-diphosphoglycerate in relation to body weight.
The oxygen affinity of mammalian hemoglobins in the absence of 2,3-diphosphoglycerate in relation to body weight.
复制标题
在没有 2,3-二磷酸甘油酸的情况下，哺乳动物血红蛋白的氧亲和力与体重的关系。
DOI：
10.1016/0300-9629(85)90437-2
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Ikai Atsushi
中科院分区：
文献类型：
--
作者：
Nakashima Masae;Noda Haruhiko;Hasegaea Masami;Ikai Atsushi
我们研究了哺乳动物血红蛋白的氧合作用：小鼠 (Mus musculus molossinus)、兔 (Oryctolagus cuniculus Domesticus)、日本猴 (Macaca fuscata)、人 (Homo sapiens)、绵羊 (Ovis aries)、美洲驼 (Lama glama)、猪 (Sus scrofa Domesticus)、牛 (Bos taurus homeus) 和马 (Equus caballus)，在没有 2, 3-二磷酸甘油酯 (DPG) 的情况下，并比较了它们的氧亲和力与体重的关系。 Schmidt-Nielsen 和 Larimer (1958) 观察到的体重与全血氧亲和力之间的负相关性在不存在 DPG 的情况下并未观察到。我们的结果表明，血红蛋白在氧亲和力与动物体重之间的适应性进化只能通过 DPG 来理解。
We studied the oxygenation of mammalian hemoglobins: mouse (Mus musculus molossinus), rabbit (Oryctolagus cuniculus domesticus), Japanese monkey (Macaca fuscata), man (Homo sapiens), sheep (Ovis aries), llama (Lama glama), pig (Sus scrofa domesticus), cow (Bos taurus domesticus) and horse (Equus caballus), in the absence of 2, 3-diphosphoglycerate (DPG) and compared their oxygen affinity in relation to the body weight. The negative correlation between body weight and the oxygen affinity of the whole blood, observed by Schmidt-Nielsen and Larimer (1958), was not observed in the absence of DPG. Our results indicated that an adaptive evolution proposed for hemoglobin in terms of its oxygen affinity vs body weight of the animal can only be appreciated with DPG.