Presynaptic dopaminergic dysfunction in schizophrenia -: A positron emission tomographic [18F]fluorodopa study
Presynaptic dopaminergic dysfunction in schizophrenia -: A positron emission tomographic [18F]fluorodopa study
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DOI：
10.1001/archpsyc.61.2.134
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发表时间：
2004-02-01
影响因子：
--
通讯作者：
Grasby, P
中科院分区：
文献类型：
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作者：
McGowan, S;Lawrence, AD;Grasby, P
背景：精神分裂症的多巴胺过度活跃假说仍然是该疾病病理生理学最有影响力的理论之一。放射性示踪剂脑成像研究，现在直接测试方面的过度活跃hypothesis.Objective：评估突触前多巴胺能功能在一个大的队列的精神分裂症患者通过[F-18]氟多巴摄取和高灵敏度的三维正电子发射断层扫描仪。我们预测了精神分裂症患者纹状体[F-18]氟多巴摄取的升高和前额叶皮质[F-18]氟多巴摄取的降低。设计：病例对照研究。设置：研究机构调查招募医院门诊患者。患者：16例DSM-IV诊断为精神分裂症的男性医院门诊患者（平均年龄38岁）和12名年龄匹配的无精神和神经疾病的男性志愿者。干预：[F-18]氟多巴正电子发射断层扫描。主要结果测量：[F-18]氟多巴摄取常数Ki采用统计参数图和感兴趣区分析测量。
Context: The dopamine overactivity hypothesis of schizophrenia remains one of the most influential theories of the pathophysiology of the illness. Radiotracer brain imaging studies are now directly testing aspects of the overactivity hypothesis.Objective: To assess presynaptic dopaminergic function in a large cohort of patients with schizophrenia by means of [F-18]fluorodopa uptake and a high-sensitivity 3-dimensional positron emission tomograph. We predicted elevations in striatal [F-18]fluorodopa uptake and reductions in prefrontal cortical [F-18]fluorodopa uptake in patients with schizophrenia.Design: Case-control study.Setting: Research institute investigation recruiting hospital outpatients.Patients: Sixteen male medicated hospital outpatients with a DSM-IV diagnosis of schizophrenia (mean age, 38 years) and 12 age-matched male volunteers free of psychiatric and neurologic illness.Intervention: [F-18]fluorodopa positron emission tomographic scanning.Main Outcome Measure: [F-18]fluorodopa uptake constant K-i measured with statistical parametric mapping and region-of-interest analyses.Results: Statistical parametric mapping (P