Age-related changes in plasma catecholamine responses to chronic intermittent stress.
Age-related changes in plasma catecholamine responses to chronic intermittent stress.
复制标题
血浆儿茶酚胺对慢性间歇性应激反应的年龄相关变化。
DOI：
10.1016/0031-9384(94)00387-k
复制
发表时间：
1995
影响因子：
2.9
通讯作者：
McCarty,R
中科院分区：
文献类型：
--
作者：
Mabry,TR;Gold,PE;McCarty,R
我们研究了年轻成年（3个月）和老年（22个月）Fischer 344（F-344）雄性大鼠对应激刺激的血浆儿茶酚胺反应的习惯化和致敏性。与年轻的成年对照组相比，老年大鼠暴露于束缚应激后血浆去甲肾上腺素（NE）和肾上腺素（EPI）水平升高更大。在年龄范围内，第一次应激的大鼠血浆儿茶酚胺反应与第27次应激的大鼠相似。当慢性应激的年轻成年和老年F-344大鼠暴露于一种新的应激源，在25°C游泳应激，血浆儿茶酚胺反应显着大于年龄匹配的处理控制。年轻成年和老年F-344大鼠的血浆儿茶酚胺反应对新应激源的致敏程度相似。这些结果表明，老年大鼠血浆中的儿茶酚胺反应增强急性束缚应激相比，年轻的成年人。此外，这两个年龄的大鼠显示出相当水平的致敏血浆儿茶酚胺反应的一种新的压力。这些研究结果强调，老年大鼠不同于年轻的成年大鼠在某些方面，但不是所有方面的交感肾上腺髓质调节。此外，这些年龄相关的差异，交感肾上腺髓质反应时，动物暴露于应激刺激被揭露。
We examined habituation and sensitization of plasma catecholamine responses to stressful stimulation in young adult (3 months) and aged (22 months) Fischer 344 (F-344) male rats. Aged rats had greater elevations in plasma levels of norepinephrine (NE) and epinephrine (EPI) following exposure to restraint stress compared to young adult controls. Within ages, plasma catecholamine responses were similar in rats stressed for the first time compared to those stressed for the 27th time. When chronically stressed young adult and aged F-344 rats were exposed to a novel stressor, swim stress at 25°C, plasma catecholamine responses were significantly greater than for age-matched handled controls. The magnitude of sensitization of plasma catecholamine responses to the novel stressor was similar for young adult and aged F-344 rats. These results indicate that aged rats have enhanced plasma catecholamine responses to acute restraint stress compared to young adults. In addition, rats of both ages displayed comparable levels of sensitization of plasma catecholamine responses to a novel stressor. These findings emphasize that aged rats differ from young adult rats in some but not all aspects of sympathetic-adrenal medullary regulation. Further, these age-related differences in sympathetic-adrenal medullary responses are unmasked when animals are exposed to stressful stimulation.