New cytotoxic sesquiterpenoid nitrobenzoyl esters from a marine isolate of the fungus Aspergillus versicolor
New cytotoxic sesquiterpenoid nitrobenzoyl esters from a marine isolate of the fungus Aspergillus versicolor
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DOI：
10.1016/s0040-4020(97)10396-9
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发表时间：
1998-02-26
期刊：
影响因子：
2.1
通讯作者：
Fenical, W
中科院分区：
文献类型：
--
作者：
Belofsky, GN;Jensen, PR;Fenical, W
从从加勒比海绿色青霉Capitatus表面分离的杂色曲霉（Aspergillusversicolor）的培养液和菌丝体的有机提取物中分离得到四个新的倍半萜硝基苯甲酰酯（1-4）。4个化合物的结构通过H-1 NMR、C-13 NMR、HMQC和HMBC数据的广泛分析确定。9 α，14-二羟基-6 β-对硝基苯甲酰肉桂醛（1）在体外对HCT-116人结肠癌细胞显示出显著的细胞毒性，并对一组肾肿瘤细胞系显示出中等选择性的细胞毒性。(C)1998爱思唯尔科学有限公司阿里版权所有。
Four new sesquiterpenoid nitrobenzoyl esters (1-4) have been isolated from organic extracts of the culture broth and mycelia of Aspergillus versicolor, a fungus isolated from the surface of the Caribbean green alga Penicillus capitatus. The structures of the four compounds were determined through extensive analysis of H-1 NMR, C-13 NMR, HMQC, and HMBC data. 9 alpha,14-Dihydroxy-6 beta-p-nitrobenzoylcinnamolide (1) displayed significant cytoxicity against HCT-116 human colon carcinoma cells in vitro and exhibited moderately selective cytotoxicity toward a panel of renal tumor cell lines. (C) 1998 Elsevier Science Ltd. Ali rights reserved.