Increased aortic wall stress in aortic insufficiency: clinical data and computer model
Increased aortic wall stress in aortic insufficiency: clinical data and computer model
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DOI：
10.1016/j.ejcts.2004.11.011
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发表时间：
2005-02-01
影响因子：
3.4
通讯作者：
Hagl, S
中科院分区：
文献类型：
--
作者：
Beller, CJ;Labrosse, MR;Hagl, S
目的：本研究旨在确定哪些心脏病理与主动脉纵向应力增加相关，因此可能导致主动脉夹层中可见的内膜横向撕裂。方法：对90例心脏病患者的主动脉根部造影剂注射进行分析，以测量心动周期内瓣环的向下运动。建立了主动脉根部、主动脉弓和主动脉上血管受压的有限元模型，以评估主动脉根部运动对主动脉壁应力的影响。结果如下：主动脉根部轴向位移范围为0 ~ 14 mm，多因素分析显示主动脉瓣关闭不全（Al）、左心室运动功能减退（HKI）和心肌肥厚（HTR）是与主动脉根部轴向位移（DISP）相关的3个独立变量，ARM（mm）= 5.379（P
Objective: The study was aimed at determining which cardiac pathologies are associated with increased longitudinal stress in the aorta and therefore may be responsible for the intimat transverse tears seen in aortic dissections. Methods: Aortic root contrast injections were analyzed in 90 cardiac patients to measure the downward motion of the annulus during a cardiac cycle. A finite element model of the pressurized aortic root, arch and supra-aortic vessels was created to assess the influence of the aortic root motion on the aortic wall stress. Results: The axial displacement of the aortic root ranged from 0 to 14 mm. A multivariate analysis showed that aortic insufficiency (Al) grade, hypokinesis of the left ventricle (HKI), and myocardial hypertrophy (HTR) were 3 independent variables which correlated with the axial displacement of the aortic root (DISP), such that ARM (mm) = 5.379 (P