Identification of the rat IgA Fc receptor encoded in the leukocyte receptor complex
Identification of the rat IgA Fc receptor encoded in the leukocyte receptor complex
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DOI：
10.1007/s00251-003-0626-1
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发表时间：
2004-01-01
期刊：
影响因子：
3.2
通讯作者：
Kasahara, M
中科院分区：
文献类型：
--
作者：
Maruoka, T;Nagata, T;Kasahara, M
人 FcalphaRI (CD89) 是白细胞受体复合物中编码的骨髓特异性 IgA Fc 受体。迄今为止，尚未在小鼠体内鉴定出编码 FcalphaRI 的基因。在这里，我们表明，与小鼠不同，大鼠具有编码 FcalphaRI 的基因 (Fcar)。大鼠Fcar基因具有与人类对应物基本相同的外显子-内含子结构，并在1号染色体上的白细胞受体复合物中编码。使用大鼠Fcar作为探针的Southern印迹分析显示，在中国仓鼠和沙鼠中存在杂交条带，但在小鼠中没有，这表明Fcar在小鼠的谱系分化后丢失了。 大鼠和小鼠。大鼠体内 FcalphaRI 的鉴定应有助于阐明该受体的体内作用。
Human FcalphaRI (CD89) is a myeloid-specific IgA Fc receptor encoded in the leukocyte receptor complex. Thus far, no gene coding for FcalphaRI has been identified in mice. Here, we show that, unlike mice, rats have the gene (Fcar) coding for FcalphaRI. The rat Fcar gene has an exon-intron structure essentially identical to that of the human counterpart and is encoded in the leukocyte receptor complex on Chromosome 1. Southern blot analysis using the rat Fcar as a probe revealed hybridizing bands in Chinese and Syrian hamsters and gerbils, but not in mice, indicating that Fcar was lost in the lineage leading to mice after the divergence of rats and mice. Identification of FcalphaRI in rats should facilitate the elucidation of the in vivo role of this receptor.