Neuropsychiatric symptoms and the APOE genotype in Alzheimer's disease
Neuropsychiatric symptoms and the APOE genotype in Alzheimer's disease
复制标题
DOI：
10.1007/s10072-009-0116-9
复制
发表时间：
2009-10-01
影响因子：
3.3
通讯作者：
Angelelli, Paola
中科院分区：
文献类型：
--
作者：
Del Prete, Marina;Spaccavento, Simona;Angelelli, Paola
本研究旨在探讨阿尔茨海默病（AD）的神经精神病学特征，并研究APOE基因型和其他临床变量在神经精神疾病发病中的作用。此外，还试图研究行为和精神症状的演变。入组了53例连续门诊AD患者。24例患者纵向随访1年。采用简易精神状态检查量表（MMSE）评定认知功能。采用神经精神量表（NPI）评估行为和精神症状。通过实验室检测确定基因分型。在基线时，没有特定的神经精神障碍与ApoE基因型显著相关，但与特殊的神经精神特征相关。与非等位基因携带者相比，等位基因携带者表现出更广泛的神经精神障碍，幻觉和异常运动行为评分更高。纵向结果表明，两组的趋势不同：随着时间的推移，携带者在某些症状中表现出增加/延迟发作，而在其他症状中表现出平行减少，而非携带者表现出未分化的疾病恶化。APOE基因<$4等位基因与阿尔茨海默病的发病和发展有关，APOE基因<$4等位基因与阿尔茨海默病的发病和发展有关。
The study aimed to characterize neuropsychiatric symptomatology in Alzheimer's disease (AD) and investigate the role of APOE genotype and other clinical variables in the onset of neuropsychiatric disorders. Moreover, an attempt to study the evolution of behavioral and psychiatric symptoms was made. Fifty-three consecutive outpatients with AD were enrolled. Twenty-four were followed longitudinally for 1 year. MMSE was used to evaluate cognitive functions. The neuropsychiatric inventory (NPI) was administered to assess behavioral and psychiatric symptoms. Genotyping was determined through laboratory testing. At baseline, no specific neuropsychiatric disorder was significantly associated with ApoE genotype, but associated with a peculiar neuropsychiatric profile. Patients with epsilon (4) allele showed a wider range of neuropsychiatric disturbances when compared to non-carriers and higher scores for hallucinations and aberrant motor behaviors. The longitudinal results suggest different trends in both groups: over time, epsilon (4) carriers showed an increase/delayed onset in some symptoms and a parallel decrease in others, while non-carriers presented an undifferentiated worsening of symptomatology. Clear relations with other clinical and demographic variables were also found. APOE epsilon (4) allele is associated to a peculiar neuropsychiatric profile characterizing the onset and evolution of Alzheimer's disease.