CatSper: A Unique Calcium Channel of the Sperm Flagellum.
CatSper: A Unique Calcium Channel of the Sperm Flagellum.
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DOI：
10.1016/j.cophys.2018.02.004
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发表时间：
2018-04
影响因子：
2.5
通讯作者：
Mannowetz N
中科院分区：
文献类型：
--
作者：
Lishko PV;Mannowetz N
为了克服卵子的保护性运动，确保成功受精，哺乳动物精子将对称的前向运动转换为强大的鞭状鞭毛运动，称为超激活。后者是由通过精子特异性、电压依赖性和碱化激活的精子钙通道CatSper的钙内流触发的。该通道包含9个亚基，它们一起形成异聚复合物。CatSper缺陷的雄性小鼠和CatSper基因突变的男性是不育的。这种钙通道是由各种内源性化合物，如类固醇，肾上腺素，内源性大麻素，和细胞内的pH值进行调节。作为一个精子特异性离子通道，不表达在身体的其他任何地方，CatSper代表了女性，甚至男性避孕药的发展的理想目标。在这篇综述中，我们讨论了最近的进展，在研究CatSper的功能特性，并讨论了未来的步骤，需要采取，以实现深入了解的分子基础CatSper功能。
To overcome egg protective vestments and ensure successful fertilization, mammalian spermatozoa switch symmetrical progressive motility to a powerful, whip-like flagellar motion, known as hyperactivation. The latter is triggered by a calcium influx through the sperm-specific, voltage-dependent, and alkalization-activated calcium channel of sperm - CatSper. The channel comprises nine subunits which together form a heteromeric complex. CatSper-deficient male mice and men with mutations in CatSper genes are infertile. This calcium channel is regulated by various endogenous compounds, such as steroids, prostaglandins, endocannabinoids, and intracellular pH. Being a sperm-specific ion channel that is not expressed anywhere else in the body, CatSper represents an ideal target for the development of female and even male contraceptives. In this review, we discuss the recent advances in studying CatSper functional properties and discuss future steps that are required to take in order to achieve a deep understanding of the molecular basis of CatSper function.