sart-3 functions to regulate germline sex determination in C. elegans .
sart-3 functions to regulate germline sex determination in C. elegans .
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SART-3功能可调节秀丽隐杆线虫中种系性别的确定。
DOI：
10.17912/micropub.biology.000820
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发表时间：
2023
影响因子：
--
通讯作者：
Arur, Swathi
中科院分区：
文献类型：
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作者：
Furuta, Tokiko;Arur, Swathi
秀丽隐杆线虫基因 sart-3 首次被鉴定为人类 SART3（T 细胞识别的 S 鳞状细胞癌抗原 R 3）的同源物。在人类中，SART3 的表达与鳞状细胞癌相关，因此大多数研究集中于其作为癌症免疫治疗靶点的潜在作用（Shichijo 等人，1998；Yang 等人，1999）。此外，在 HIV 病毒宿主激活途径中，SART3 也被称为 Tip110（Liu et al. 2002；Whitmill et al. 2016）。尽管进行了这些与疾病相关的研究，但直到酵母同源物被鉴定为剪接体 U4/U6 snRNP 回收因子后，该蛋白质的分子功能才被揭示（Bell 等人，2002）。然而，SART3 在发育过程中的功能仍然未知。在这里，我们报道线虫 sart-3 突变体雌雄同体在成年期表现出 Mog（生殖细胞的男性化）表型，表明 sart-3 正常功能是调节从生精到卵子配子性别的转换。
Caenorhabditis elegans gene sart-3 was first identified as the homolog of human SART3 ( S quamous cell carcinoma A ntigen R ecognized by T -cells 3). In humans, expression of SART3 is associated with squamous cell carcinoma, thus most of the studies focus on its potential role as a target of cancer immunotherapy (Shichijo et al. 1998; Yang et al. 1999). Furthermore, SART3 is also known as Tip110 (Liu et al. 2002; Whitmill et al. 2016) in the context of HIV virus host activation pathway. Despite these disease related studies, the molecular function of this protein was not revealed until the yeast homolog was identified as spliceosome U4/U6 snRNP recycling factor (Bell et al. 2002). The function of SART3 in development, however, remains unknown. Here we report that the C. elegans sart-3 mutant hermaphrodites exhibit a Mog ( M asculinization O f the G ermline) phenotype in adulthood suggesting that sart-3 normally functions to regulate the switch from spermatogenic to oogenic gametic sex.