Abortion in mice induced by intravenous injections of antibodies to type IV collagen or laminin.
Abortion in mice induced by intravenous injections of antibodies to type IV collagen or laminin.
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静脉注射 IV 型胶原蛋白或层粘连蛋白抗体引起小鼠流产。
DOI：
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发表时间：
1983
影响因子：
6
通讯作者：
L. Liotta
中科院分区：
文献类型：
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作者：
J. Foidart;M. Yaar;A. Figueroa;A. Wilk;K. Brown;L. Liotta
纯化的抗体层粘连蛋白或IV型胶原静脉注射给孕鼠被发现定位在基底膜的所有母体组织，以及壁和内脏卵黄囊和滋养层基底膜，但不是在胚胎组织。IV型胶原抗体诱导流产、胎盘后血肿和胎儿死亡的发生率较高。当静脉给药时，两种抗血清均具有胚胎毒性。抗体附着于这些特异性基底膜抗原的功能后果似乎是壁和内脏卵黄囊内出血以及胎儿与母体组织分离。补体激活似乎在妊娠中断中起着重要作用，因为在缺乏补体第五组分C5的小鼠品系中，在通过施用眼镜蛇毒因子耗尽C3的小鼠中，或在注射IV型胶原蛋白或层粘连蛋白的抗体的F（ab）片段的小鼠中没有观察到补体激活。
Purified antibodies to laminin or Type IV collagen administered intravenously to pregnant mice were found to localize in the basement membranes of all maternal tissues as well as the parietal and visceral yolk sacs and trophoblast basement membranes but not in embryonic tissues. Antibodies to Type IV collagen induced a higher incidence of abortions, retroplacental hematomas and fetal deaths. When administered intraamniotically, both antiserums were embryotoxic. The functional consequences of the attachment of antibodies to these specific basement membrane antigens appear to be hemorrhage within the parietal and visceral yolk sacs and separation of fetal from maternal tissues. Complement activation appears to play an important role in the interruptions of pregnancy, because this was not observed in strains of mice lacking C5, the fifth component of complement, in mice depleted of C3 by administration of cobra venom factor, or in mice injected with the F(ab) fragments of antibody to Type IV collagen or laminin.