Risk factors for incident cortical and posterior subcapsular lens opacities in the Barbados eye studies
Risk factors for incident cortical and posterior subcapsular lens opacities in the Barbados eye studies
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DOI：
10.1001/archopht.122.4.525
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发表时间：
2004-04-01
影响因子：
--
通讯作者：
Leske, C
中科院分区：
文献类型：
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作者：
Hennis, A;Wu, SY;Leske, C
目的：评估皮质和后囊膜（PSC）镜头不良发病率的危险因素。设计：基于人群的队列研究，在4年随访中参与85％的参与。巴巴多斯眼睛研究的三名黑人参与者，西印度群岛巴巴多斯，其中2040年和2954年分别不含皮质和PSC镜头差异。血压测量和眼科测量值，包括slitlamp镜头分级，眼底摄影和眼科检查。通过逻辑回归评估了与出现皮质和PSC不透明的因素（镜片不透不在属分类系统II，大于或等于2）。迈因结果度量：具有95％置信区间的相对风险（RRS）。置信区间：回报：4年的发病率：皮质晶状体的不相处为22.2％（452/2040），增加风险的因素是年龄较大，女性性别（RR = 1.3），低社会经济状况（RR = 1.4）和糖尿病史（RR = 2.4），而阿司匹林的历史使用与较低的RR相关（RR = 0.2; 95％置信区间，0.1-0.8），这是基于少量的结果。 PSC不透明的4年发病率降低了3.3％（97/2954），随着年龄的增长和糖尿病病史的风险也增加（RR = 2.9）。剂量反应之间的关系之间存在剂量反应之间的关系和基线时糖基化血红蛋白的水平增加，皮质风险最高（RR = 3.60; 95％置信区间，2.23-5.81）和PSC（RR = 4.93; 95％; 95％; 95％; 95％; 95％; 95％; 95％，置信间隔，2.69-9.05）更薄的不透明性和11.5％的糖基化血红蛋白水平。结论：糖尿病和高血糖症是这种非洲糖尿病患者较高糖尿病率的皮质和PSC镜头不透明的主要风险因素。预防和改善糖尿病的控制可能会减轻白内障的负担。鉴于其潜在的预防白内障的潜力，阿司匹林使用者中皮质晶状体不良发生率降低的发现。
Objective: To evaluate risk factors for the 4-year incidence of cortical and posterior subcapsular (PSC) lens opacities.Design: Population-based cohort study with 85% participation at 4-year follow-up.Participants: Three thousand one hundred ninety-three black participants of the Barbados Eye Studies, Barbados, West Indies, of whom 2040 and 2954 were free of cortical and PSC lens opacities, respectively, at baseline.Methods: The standardized protocol at baseline and follow-up included an interview, anthropometric and blood pressure measurements, and ophthalmic measurements including slitlamp lens grading, fundus photography, and an ophthalmologic examination. Factors associated with incident cortical and PSC opacities (Lens Opacities Classification System II, greater than or equal to2) were evaluated by logistic regression.Main Outcome Measure: Relative risks (RRs) with 95% confidence intervals.Results: The 4-year incidence of cortical lens opacities was 22.2% (452/2040) the factors increasing risk were older age, female gender (RR=1.3), low socioeconomic status (RR=1.4), and a history of diabetes mellitus (RR=2.4), while aspirin use was associated with a lower RR (RR=0.2; 95% confidence interval, 0.1-0.8), a result based on small numbers. The 4-year incidence of PSC opacities was lower at 3.3% (97/2954), and risk also increased with age and a history of diabetes mellitus (RR=2.9). A dose-response relationship was evident between incident opacities and increased levels of glycosylated hemoglobin at baseline, with the highest risk of cortical (RR=3.60; 95% confidence interval, 2.23-5.81) and PSC (RR=4.93; 95%, confidence interval, 2.69-9.05) opacities at more thin an 11.5% glycosylated hemoglobin level.Conclusions: Diabetes mellitus and hyperglycemia are major modifiable risk factors for the development of cortical and PSC lens opacities in this African-descent population with a high rate of diabetes mellitus. Prevention and improved control of diabetes mellitus are likely to reduce the burden of cataract. The finding of a reduced incidence of cortical lens opacities in aspirin users merits further investigation, given its potential for cataract prevention.