Mast cells in airway diseases and interstitial lung disease.
Mast cells in airway diseases and interstitial lung disease.
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DOI：
10.1016/j.ejphar.2015.04.046
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发表时间：
2016-05-05
影响因子：
5
通讯作者：
Bradding P
中科院分区：
文献类型：
--
作者：
Cruse G;Bradding P
肥大细胞是炎症的主要效应细胞，有强有力的证据表明肥大细胞在哮喘病理生理中起着重要作用。也有越来越多的证据表明肥大细胞有助于其他炎症性和纤维化性肺部疾病，如慢性阻塞性肺病和特发性肺纤维化。这篇综述讨论了肥大细胞在气道疾病中的作用，并强调了肥大细胞在特定肺室中的微定位及其细胞相互作用可能对其在疾病中的效应功能至关重要。
Mast cells are major effector cells of inflammation and there is strong evidence that mast cells play a significant role in asthma pathophysiology. There is also a growing body of evidence that mast cells contribute to other inflammatory and fibrotic lung diseases such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. This review discusses the role that mast cells play in airway diseases and highlights how mast cell microlocalisation within specific lung compartments and their cellular interactions are likely to be critical for their effector function in disease.