IgA antibodies to phosphocholine associate with long-term cardiovascular disease risk
IgA antibodies to phosphocholine associate with long-term cardiovascular disease risk
复制标题
DOI：
10.1016/j.atherosclerosis.2017.12.010
复制
发表时间：
2018-02-01
期刊：
影响因子：
5.3
通讯作者：
Horkko, Sohvi
中科院分区：
文献类型：
--
作者：
Kankaanpaa, Jari;Sampi, Maritta;Horkko, Sohvi
背景和目的：磷酸胆碱和氧化低密度脂蛋白（oxLDL）的抗体被认为可以改变动脉粥样硬化的进展。我们研究了磷酸胆碱（PCo）、肺炎链球菌细胞壁多糖（CWPS）和oxLDL抗体在确定长期CVD生存中的预后价值。方法：对欧卢项目阐明动脉粥样硬化风险研究（OPERA）的1044例受试者的CVD发病率进行了18年的随访，并分析了基线血浆PCo、CWPS和oxLDL抗体IgM、IgG和伊加水平。结果：在随访期间，195例受试者（18.7%）发生了CVD事件。考克斯模型与ACC/AHA CVD校正（ASCVD）显示，伊加水平PCho和伊加的CWPS是有统计学意义的预测CVD风险的因素。在调整其他危险因素后，PCo，CWPS和oxLDL的IgM和IgG抗体对CVD风险没有影响。ASCVD风险模型中加入IgA-PCho后，净重新分类改善（分类：17年风险30%）为0.06（-0.001-0.12，p < 0.054），IDI为0.0124（0.0036-0.0211，p < 0.006）。17例（9.4%）发生CVD事件的研究受试者被正确重新分类为较高风险类别，9例（5.0%）受试者被分类为较低风险类别。在非病例中，58例（8.7%）受试者被正确地重新分类为低风险，46例（5.9%）被重新分类为高风险category.Conclusions：血浆伊加抗体PCo和肺炎链球菌CWPS是长期CVD风险的重要预测因子。关于伊加抗体在动脉粥样硬化和CVD中的作用的进一步研究是必要的。(C)2017 Elsevier B. V.版权所有。
Background and aims: Antibodies to phosphocholine and oxidized LDL (oxLDL) are proposed to modify progression of atherosclerosis. We investigated the prognostic value of antibodies to phosphocholine (PCho), Streptococcus pneumoniae cell wall polysaccharide (CWPS) and oxLDL in defining long-term CVD survival.Methods: CVD incidence was followed for 18 years and analyzed with baseline plasma IgM, IgG and IgA antibody levels to PCho, CWPS and oxLDL in 1044 subjects of Oulu Project Elucidating Risk of Atherosclerosis study (OPERA).Results: During the follow-up period, 195 subjects (18.7%) had a CVD event. Cox model with ACC/AHA CVD adjustments (ASCVD) showed that IgA levels to PCho and IgA to CWPS were statistically significant factors predicting CVD risk. IgM and IgG antibodies to PCho, CWPS and oxLDL had no effect on CVD risk after adjusting for other risk factors. Net reclassification improvement (categories: 17-year risk 30%), was 0.06 (-0.001-0.12, p < 0.054), and IDI was 0.0124 (0.0036-0.0211, p < 0.006) with IgA-PCho added to the ASCVD risk model. Seventeen (9.4%) study subjects with CVD events were correctly reclassified into higher risk category while 9 (5.0%) subjects were classified into lower risk category. Among the non-cases, 58 (8.7%) subjects were correctly reclassified into lower risk, and 46 (5.9%) were reclassified into higher risk category.Conclusions: Plasma IgA antibodies to PCho and Streptococcus pneumoniae CWPS are significant predictors of long-term CVD risk. Additional studies on the role of IgA antibodies in atherogenesis and CVD are warranted. (C) 2017 Elsevier B.V. All rights reserved.