Pathogenesis of Cardiovascular Disease in Diabetes
Pathogenesis of Cardiovascular Disease in Diabetes
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DOI：
10.1016/j.ecl.2017.10.010
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发表时间：
2018-03-01
影响因子：
4.5
通讯作者：
McDonnell, Marie E.
中科院分区：
文献类型：
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作者：
Haas, Andrea V.;McDonnell, Marie E.
成人糖尿病患者最常见的死亡原因是心血管疾病（CVD）。本文对糖尿病心血管疾病的发病机制作一简要综述，探讨了动脉粥样硬化、微血管病变、糖尿病性心肌病和心脏自主神经病变等4种常见疾病，并举例说明了它们是由相关的发病因素引起的。这些诊断中的每一种都可以单独存在，或者由于重叠的病理生理学而与其他诊断一起沿着共同存在。虽然糖尿病环境的生理异常谱很广，超出了高血糖，但作者强调了最相关的证据，支持目前对糖尿病CVD的潜在因素的认识。
The most common cause of death among adults with diabetes is cardiovascular disease (CVD). In this concise review on pathogenesis of CVD in diabetes, the 4 common conditions, atherosclerosis, microangiopathy, diabetic cardiomyopathy, and cardiac autonomic neuropathy, are explored and illustrated to be caused by interrelated pathogenetic factors. Each of these diagnoses can present alone or, commonly, along with others owing to overlapping pathophysiology. Although the spectrum of physiologic abnormalities that characterize the diabetes milieu is broad and goes beyond hyperglycemia, the authors highlight the most relevant evidence supporting the current knowledge of potent factors that contribute to CVD in diabetes.