Relation of coronary artery disease and cerebrovascular disease with atherosclerosis of the thoracic aorta in the general population
Relation of coronary artery disease and cerebrovascular disease with atherosclerosis of the thoracic aorta in the general population
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DOI：
10.1016/s0002-9149(01)02225-1
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发表时间：
2002-02-01
影响因子：
2.8
通讯作者：
Seward, JB
中科院分区：
文献类型：
--
作者：
Agmon, Y;Khandheria, BK;Seward, JB
临床冠状动脉疾病、脑血管疾病和主动脉粥样硬化之间的关联尚未在普通人群中进行研究。对 581 名受试者进行了经食管超声心动图检查，这些受试者是奥姆斯特德县（明尼苏达州）年龄大于或等于 45 岁的人群的随机样本，参与了中风预防：社区风险评估 (SPARC) 研究。确定了人群中胸主动脉粥样硬化的频率和严重程度，并检查了临床冠状动脉疾病、脑血管疾病和主动脉粥样硬化之间的关联。既往心肌梗死、心绞痛和冠状动脉搭桥手术与主动脉粥样硬化显着相关，调整年龄和性别后（p小于或等于0.01）。在患有动脉粥样硬化的受试者中，这些表现与复杂的动脉粥样硬化（斑块> 4毫米厚、溃疡斑块或移动碎片）相关，根据年龄和性别进行调整（p < 0.2）。因此，冠状动脉疾病与一般人群中的主动脉粥样硬化和复杂动脉粥样硬化密切相关。脑血管疾病与主动脉粥样硬化的相关性较弱，因此质疑主动脉粥样硬化在普通人群脑血管事件发病机制中的整体重要性。 (C) 2002 年，Excerpta Medica, Inc.
The association between clinical coronary artery disease, cerebrovascular disease, and aortic atherosclerosis has not been examined in the general population. Transesophageal echocardiography was performed in 581 subjects, a random sample of the Olmsted County (Minnesota) population aged greater than or equal to45 years, participating in the Stroke Prevention: Assessment of Risk in a Community (SPARC) study. The frequency and severity of atherosclerosis of the thoracic aorta were determined in the population and the association between clinical coronary artery disease, cerebrovascular disease, and aortic atherosclerosis was examined. Previous myocardial infarction, angina pectoris, and coronary artery bypass surgery were significantly associated with aortic atherosclerosis, adjusting for age and gender (p less than or equal to 0.01). Among subjects with atherosclerosis, these manifestations were associated with complex atherosclerosis (plaques >4-mm thick, ulcerated plaques, or mobile debris), adjusting for age and gender (p 0.2). Thus, coronary artery disease is strongly associated with aortic atherosclerosis and complex atherosclerosis in the general population. Cerebrovascular disease is weakly associated with aortic atherosclerosis, thereby questioning the overall importance of aortic atherosclerosis in the pathogenesis of cerebrovascular events in the general population. (C) 2002 by Excerpta Medica, Inc.