Higher HDL cholesterol levels are associated with increased markers of interstitial myocardial fibrosis in the MultiEthnic Study of Atherosclerosis (MESA).
Higher HDL cholesterol levels are associated with increased markers of interstitial myocardial fibrosis in the MultiEthnic Study of Atherosclerosis (MESA).
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DOI：
10.1038/s41598-023-46811-8
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发表时间：
2023-11-17
影响因子：
4.6
通讯作者：
Rodriguez, Annabelle
中科院分区：
文献类型：
--
作者：
Chehab, Omar;Akl, Elie;Abdollahi, Ashkan;Zeitoun, Ralph;Ambale-Venkatesh, Bharath;Wu, Colin;Tracy, Russell;Blumenthal, Roger S.;Post, Wendy S.;Lima, Joao A. C.;Rodriguez, Annabelle
新的研究表明，高密度脂蛋白-C水平可能不是心脏保护，可能会恶化心血管疾病(CVD)的预后。然而，目前还没有关于高密度脂蛋白-C与其他心血管危险因素如心肌纤维化的相关性的数据，心肌纤维化是心脏重构预测负面结果的一个关键方面。因此，我们的目标是研究高密度脂蛋白水平与间质性心肌纤维化(IMF)和心肌瘢痕的关系，分别通过CMR T1标测和晚期Gd增强(LGE)来测量。有1863名参与者(平均年龄69岁)既有血清高密度脂蛋白胆固醇测量，又接受了CMR。对有可用的间质纤维化指标(细胞外体积分数[ECV]；N = 1172和Native-T1；N = 1863)和LGE替代纤维化(N = 1172)的患者进行分析。高密度脂蛋白胆固醇( -C)经对数变换后归类为 40(低)、40-59(正常)和≥ 60 mg/dL(高)。建立多变量线性回归模型和Logistic回归模型，分别评估高密度脂蛋白胆固醇与CMR测量的IMF、ECV%和Native-T1时间以及心肌瘢痕的相关性。在完全调整的模型中，对数高密度脂蛋白胆固醇每增加1-SD，ECV%增加1%(p = 0.001)，而Native-T1增加18毫秒(p <； 0.001)。当按高密度脂蛋白胆固醇分类时，高高密度脂蛋白胆固醇(≥ 60 mg/dL)组的ECV(β = 0.5%，p = 0.0 1)和自然T1(β = 7 0ms，p = 0.0 1)显著高于高密度脂蛋白胆固醇正常组。低密度脂蛋白胆固醇者与国际货币基金组织无关。排除有心肌梗死病史的个体后，结果保持不变。无论是高密度脂蛋白胆固醇水平的升高，还是任何高密度脂蛋白胆固醇类别，都与心肌瘢痕的发生率无关。高密度脂蛋白胆固醇水平的升高与国际货币基金组织标志物的增加有关，而那些高密度脂蛋白胆固醇水平高的人在社区环境中与亚临床纤维化有关。
Emerging research indicates that high HDL-C levels might not be cardioprotective, potentially worsening cardiovascular disease (CVD) outcomes. Yet, there is no data on HDL-C's association with other CVD risk factors like myocardial fibrosis, a key aspect of cardiac remodeling predicting negative outcomes. We therefore aimed to study the association between HDL-C levels with interstitial myocardial fibrosis (IMF) and myocardial scar measured by CMR T1-mapping and late-gadolinium enhancement (LGE), respectively. There were 1863 participants (mean age of 69 years) who had both serum HDL-C measurements and underwent CMR. Analysis was done among those with available indices of interstitial fibrosis (extracellular volume fraction [ECV]; N = 1172 and native-T1; N = 1863) and replacement fibrosis by LGE (N = 1172). HDL-C was analyzed as both logarithmically-transformed and categorized into < 40 (low),40–59 (normal), and ≥ 60mg/dL (high). Multivariable linear and logistic regression models were constructed to assess the associations of HDL-C with CMR-obtained measures of IMF, ECV% and native-T1 time, and myocardial scar, respectively. In the fully adjusted model, each 1-SD increment of log HDL-C was associated with a 1% increment in ECV% (p = 0.01) and an 18-ms increment in native-T1 (p < 0.001). When stratified by HDL-C categories, those with high HDL-C (≥ 60mg/dL) had significantly higher ECV (β = 0.5%, p = 0.01) and native-T1 (β = 7 ms, p = 0.01) compared with those with normal HDL-C levels. Those with low HDL-C were not associated with IMF. Results remained unchanged after excluding individuals with a history of myocardial infarction. Neither increasing levels of HDL-C nor any HDL-C category was associated with the prevalence of myocardial scar. Increasing levels of HDL-C were associated with increased markers of IMF, with those with high levels of HDL-C being linked to subclinical fibrosis in a community-based setting.
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影响因子：
32.4
作者：
Speer, Thimoteus;Rohrer, Lucia;Landmesser, Ulf
通讯作者：
Landmesser, Ulf
影响因子：
14
作者：
Puntmann, Valentina O.;Carr-White, Gerry;Nagel, Eike
通讯作者：
Nagel, Eike
DOI：
10.1152/ajpregu.00309.2015
发表时间：
2016-06-01
影响因子：
2.8
作者：
Hellstrom, Martin;Ericsson, Madelene;Hedman, Hakan
通讯作者：
Hedman, Hakan
影响因子：
24
作者：
Liu, Chang;Dhindsa, Devinder;Quyyumi, Arshed A.
通讯作者：
Quyyumi, Arshed A.
影响因子：
158.5
作者：
Barter, Philip J.;Caulfield, Mark;Brewer, Bryan
通讯作者：
Brewer, Bryan