Brief perinatal hypoxia impairs postnatal development of the bronchiolar epithelium.
Brief perinatal hypoxia impairs postnatal development of the bronchiolar epithelium.
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短暂的围产期缺氧会损害产后细支气管上皮的发育。
DOI：
10.1152/ajplung.1989.257.2.l80
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Massaro,D
中科院分区：
文献类型：
--
作者：
Massaro,GD;Olivier,J;Massaro,D
我们将妊娠大鼠在妊娠的最后一天在10%的O2中放置小于或等于9小时加分娩开始后1-2小时（与其幼崽）。在幼仔中，这种短暂的围产期缺氧导致细支气管上皮细胞组成改变，至少持续到30天;其特征在于与对照大鼠相比，克拉拉细胞的核数密度（Nvn）较高，纤毛细胞的Nvn较低，有丝分裂中克拉拉细胞的百分比和Nvn较低。围产期缺氧也导致显着降低的体积和体积密度的分泌装置（粗面内质网和分泌颗粒）在第7天在10%O2出生的大鼠。克拉拉和纤毛细胞的Nvn和克拉拉细胞有丝分裂的数据是一致的概念，即暴露于10%的O2损害了克拉拉细胞分化成纤毛细胞，这种损害持续远远超出了暴露期。
We placed pregnant rats in 10% O2 on the last day of gestation for less than or equal to 9 h plus 1-2 h (with their pups) after the onset of delivery. In the pups this brief perinatal hypoxia led to an altered cellular composition of the bronchiolar epithelium that persisted at least to age 30 days; it was characterized by a higher nuclear numerical density (Nvn) of Clara cells, a lower Nvn of ciliated cells, and a lower percentage and Nvn of Clara cells in mitoses compared with control rats. The perinatal hypoxia also led to a significantly lower volume and volume density of the secretory apparatus (rough endoplasmic reticulum and secretory granules) on day 7 in 10% O2-born rats. The data on the Nvn of Clara and ciliated cells and on Clara cell mitoses are consistent with the notion that exposure to 10% O2 impaired the differentiation of Clara cells into ciliated cells and this impairment persisted well beyond the period of exposure.